Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives

A novel series of 5-benzylidene-2-[(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 3a-i has been synthesized. 2-[(Pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 2a-c were also obtained and used as intermediates to give the target compounds. The in vitro cytotoxic activity was evaluated...

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Detalles Bibliográficos
Autores principales: Neto, Eraldo A. G., Araújo, Janete M., Rodrigues, Maria D., Silva, Teresinha G., Carneiro do Nascimento, Silene, Militão, Gardênia C.G., Góes, Alexandre José da Silva, Lima, José G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
antimicrobial activity; antiproliferative activity; cytotoxicity; 4-Thiazolidinone
Productos con Acción Antimicrobiana
Citotoxinas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/18095
http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:A novel series of 5-benzylidene-2-[(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 3a-i has been synthesized. 2-[(Pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 2a-c were also obtained and used as intermediates to give the target compounds. The in vitro cytotoxic activity was evaluated for both series. The findings obtained showed that the compounds 2a, 2b, 3b and 3c were effective against the HEp-2 cell lines with IC50 in the 1.6 - 0.5 μg/mL range, whereas the compounds 2a (IC50 = 3.6 μg/mL), 2b (IC50 = 2.4 μg/mL) and 3f (IC50 = 3.5 μg/mL) showed good inhibitory effects against HT-29 cell lines. As complementary biological test, all 4-thiazolidinones were evaluated for antimicrobial activity against various bacterial and fungal species.

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