Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives

A novel series of 5-benzylidene-2-[(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 3a-i has been synthesized. 2-[(Pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 2a-c were also obtained and used as intermediates to give the target compounds. The in vitro cytotoxic activity was evaluated...

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Autores principales:	Neto, Eraldo A. G., Araújo, Janete M., Rodrigues, Maria D., Silva, Teresinha G., Carneiro do Nascimento, Silene, Militão, Gardênia C.G., Góes, Alexandre José da Silva, Lima, José G.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia antimicrobial activity; antiproliferative activity; cytotoxicity; 4-Thiazolidinone Productos con Acción Antimicrobiana Citotoxinas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/18095 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antimicrobial activity; antiproliferative activity; cytotoxicity; 4-Thiazolidinone Productos con Acción Antimicrobiana Citotoxinas
spellingShingle	Farmacia antimicrobial activity; antiproliferative activity; cytotoxicity; 4-Thiazolidinone Productos con Acción Antimicrobiana Citotoxinas Neto, Eraldo A. G. Araújo, Janete M. Rodrigues, Maria D. Silva, Teresinha G. Carneiro do Nascimento, Silene Militão, Gardênia C.G. Góes, Alexandre José da Silva Lima, José G. Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
topic_facet	Farmacia antimicrobial activity; antiproliferative activity; cytotoxicity; 4-Thiazolidinone Productos con Acción Antimicrobiana Citotoxinas
description	A novel series of 5-benzylidene-2-[(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 3a-i has been synthesized. 2-[(Pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-ones 2a-c were also obtained and used as intermediates to give the target compounds. The in vitro cytotoxic activity was evaluated for both series. The findings obtained showed that the compounds 2a, 2b, 3b and 3c were effective against the HEp-2 cell lines with IC50 in the 1.6 - 0.5 μg/mL range, whereas the compounds 2a (IC50 = 3.6 μg/mL), 2b (IC50 = 2.4 μg/mL) and 3f (IC50 = 3.5 μg/mL) showed good inhibitory effects against HT-29 cell lines. As complementary biological test, all 4-thiazolidinones were evaluated for antimicrobial activity against various bacterial and fungal species.
format	Articulo Articulo
author	Neto, Eraldo A. G. Araújo, Janete M. Rodrigues, Maria D. Silva, Teresinha G. Carneiro do Nascimento, Silene Militão, Gardênia C.G. Góes, Alexandre José da Silva Lima, José G.
author_facet	Neto, Eraldo A. G. Araújo, Janete M. Rodrigues, Maria D. Silva, Teresinha G. Carneiro do Nascimento, Silene Militão, Gardênia C.G. Góes, Alexandre José da Silva Lima, José G.
author_sort	Neto, Eraldo A. G.
title	Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
title_short	Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
title_full	Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
title_fullStr	Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
title_full_unstemmed	Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives
title_sort	synthesis, cytotoxic and antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one derivatives
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/18095 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_9.pdf
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Synthesis, Cytotoxic and Antimicrobial activities of 5-benzylidene-2- [(pyridine-2-ylmethylene)hydrazono]-thiazolidin-4-one Derivatives

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