Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents
Development of new antibacterial agents is increasingly important due to the resistance of microbes to the known antibacterial drugs. A series of benzylidene oxazolo/thiazolo (3,2-a)-pyrimidine-6- carboxamides were synthesized by condensing 2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine carboxamides w...
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/18046 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_1.pdf |
| Aporte de: |
| id |
I19-R120-10915-18046 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia antibacterial activity; carboxamide; oxazolopyrimidine; QSAR; thiazolopyrimidine |
| spellingShingle |
Farmacia antibacterial activity; carboxamide; oxazolopyrimidine; QSAR; thiazolopyrimidine Sawant, Ramesh L. Bansode, Charusheel Wadekar, Jyoti B. Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| topic_facet |
Farmacia antibacterial activity; carboxamide; oxazolopyrimidine; QSAR; thiazolopyrimidine |
| description |
Development of new antibacterial agents is increasingly important due to the resistance of
microbes to the known antibacterial drugs. A series of benzylidene oxazolo/thiazolo (3,2-a)-pyrimidine-6-
carboxamides were synthesized by condensing 2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine carboxamides
with various aromatic aldehydes. The structures of newly synthesized compounds were characterized by
IR and NMR spectral data. All the compounds were screened for their antibacterial activity against
Gram-positive and Gram-negative bacteria and MIC values were determined by serial dilution method.
The 2D-QSAR studies were performed on VLife MDS software. QSAR equation revealed that selected
physicochemical parameters such as Alignment Independent, Electrostatic and 2PathCount have correlation with antibacterial activity. Among synthesized benzylidene oxazolo or thiazolo (3,2-a) pyrimidine-6-
carboxamide derivatives, compounds containing electron withdrawing polar group at para position of 5-
phenyl ring and electron withdrawing non-polar group at para position of 2-benzylidene moiety of thiazolopyrimidine nucleus are better antibacterials. |
| format |
Articulo Articulo |
| author |
Sawant, Ramesh L. Bansode, Charusheel Wadekar, Jyoti B. |
| author_facet |
Sawant, Ramesh L. Bansode, Charusheel Wadekar, Jyoti B. |
| author_sort |
Sawant, Ramesh L. |
| title |
Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| title_short |
Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| title_full |
Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| title_fullStr |
Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| title_full_unstemmed |
Synthesis and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| title_sort |
synthesis and qsar analysis of oxazolo/thiazolo pyrimidine derivatives as potential antibacterial agents |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/18046 http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_1_1.pdf |
| work_keys_str_mv |
AT sawantrameshl synthesisandqsaranalysisofoxazolothiazolopyrimidinederivativesaspotentialantibacterialagents AT bansodecharusheel synthesisandqsaranalysisofoxazolothiazolopyrimidinederivativesaspotentialantibacterialagents AT wadekarjyotib synthesisandqsaranalysisofoxazolothiazolopyrimidinederivativesaspotentialantibacterialagents |
| bdutipo_str |
Repositorios |
| _version_ |
1764820463684419584 |