Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs

Bovine neosporosis is a global disease caused by the protozoan parasite Neospora caninum. It is a major contributor to abortions in both dairy and beef cattle, resulting in significant economic losses annually. Domestic dogs and certain species of wild carnivores serve as definitive hosts, shedding...

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Autores principales: Bergero, Paula Elena, Campero, Lucía María, Unzaga, Juan Manuel
Formato: Articulo
Lenguaje:Español
Publicado: 2024
Materias:
Ciencias Veterinarias
Neosporosis
Mathematical Epidemiology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/179314
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-179314
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Veterinarias
Neosporosis
Mathematical Epidemiology
spellingShingle Ciencias Veterinarias
Neosporosis
Mathematical Epidemiology
Bergero, Paula Elena
Campero, Lucía María
Unzaga, Juan Manuel
Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
topic_facet Ciencias Veterinarias
Neosporosis
Mathematical Epidemiology
description Bovine neosporosis is a global disease caused by the protozoan parasite Neospora caninum. It is a major contributor to abortions in both dairy and beef cattle, resulting in significant economic losses annually. Domestic dogs and certain species of wild carnivores serve as definitive hosts, shedding oocysts into the environment through feces. Two primary transmission mechanisms have been identified: horizontal transmission, occurring through the ingestion of raw or undercooked meat containing cysts or water contaminated with oocysts, and vertical or transplacental transmission, where tachyzoites pass to the fetus. In cattle, the disease exhibits two epidemiological manifestations: endemic and epidemic abortions, known as abortion storms. Dynamic models of infectious diseases have proven valuable for studying dynamic effects and evaluating various control strategies. In this study, we present a compartmental model for neosporosis in both dairy cattle and the domestic dog population. The cattle disease submodel categorizes the population based on the infection mechanism (congenital or acquired through ingestion) to more accurately describe the two epidemiological patterns of the disease. The dog disease submodel represents disease transmission in this host, including infected cattle as a source of infection. A third submodel accounts for environmental contamination with oocysts, acting as a source of infection for cattle. Our goal was to provide a more realistic description of transmission in dairy farms by considering the complete life cycle of N. caninum.
format Articulo
Articulo
author Bergero, Paula Elena
Campero, Lucía María
Unzaga, Juan Manuel
author_facet Bergero, Paula Elena
Campero, Lucía María
Unzaga, Juan Manuel
author_sort Bergero, Paula Elena
title Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
title_short Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
title_full Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
title_fullStr Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
title_full_unstemmed Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs
title_sort mathematical modelling of neospora caninum infection in dairy cattle and domestic dogs
publishDate 2024
url http://sedici.unlp.edu.ar/handle/10915/179314
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spelling I19-R120-10915-1793142025-05-22T20:12:27Z http://sedici.unlp.edu.ar/handle/10915/179314 Mathematical modelling of Neospora caninum infection in dairy cattle and domestic dogs Modelado matemático de la infección por Neospora caninum en ganado lechero y perros domésticos Bergero, Paula Elena Campero, Lucía María Unzaga, Juan Manuel 2024 2025-05-22T14:18:47Z es Ciencias Veterinarias Neosporosis Mathematical Epidemiology Bovine neosporosis is a global disease caused by the protozoan parasite Neospora caninum. It is a major contributor to abortions in both dairy and beef cattle, resulting in significant economic losses annually. Domestic dogs and certain species of wild carnivores serve as definitive hosts, shedding oocysts into the environment through feces. Two primary transmission mechanisms have been identified: horizontal transmission, occurring through the ingestion of raw or undercooked meat containing cysts or water contaminated with oocysts, and vertical or transplacental transmission, where tachyzoites pass to the fetus. In cattle, the disease exhibits two epidemiological manifestations: endemic and epidemic abortions, known as abortion storms. Dynamic models of infectious diseases have proven valuable for studying dynamic effects and evaluating various control strategies. In this study, we present a compartmental model for neosporosis in both dairy cattle and the domestic dog population. The cattle disease submodel categorizes the population based on the infection mechanism (congenital or acquired through ingestion) to more accurately describe the two epidemiological patterns of the disease. The dog disease submodel represents disease transmission in this host, including infected cattle as a source of infection. A third submodel accounts for environmental contamination with oocysts, acting as a source of infection for cattle. Our goal was to provide a more realistic description of transmission in dairy farms by considering the complete life cycle of N. caninum. La neosporosis bovina es una enfermedad global, cuyo agente etiológico es el parásito protozoario Neospora caninum. Es la principal causa de abortos en ganado lechero y de carne, generando pérdidas económicas significativas cada año. Los perros domésticos y ciertas especies de carnívoros silvestres actúan como hospedadores definitivos, eliminando ooquistes en el ambiente a través de las heces. Se han identificado dos mecanismos principales de transmisión: la transmisión horizontal, producida por la ingestión de carnes crudas o mal cocidas con la presencia de quistes o agua contaminada con ooquistes, y la transmisión vertical o transplacentaria por el pasaje de taquizoítos al feto. En los bovinos, la enfermedad presenta dos tipos de manifestaciones epidemiológicas: abortos endémicos y epidémicos, conocidos como «tormentas de abortos». Los modelos dinámicos de enfermedades infecciosas han demostrado ser un abordaje valioso, permitiendo estudiar efectos dinámicos y la evaluación de diversas estrategias de control. En este estudio, presentamos un modelo compartimental de la neosporosis tanto para el ganado lechero como para la población de perros domésticos. El submodelo de la enfermedad en el ganado clasifica la población según el mecanismo de infección (congénito o adquirido mediante la alimentación), con el fin de describir de manera más precisa los dos patrones epidemiológicos de la enfermedad. El submodelo de la enfermedad en los perros representa la transmisión de la enfermedad en este hospedador, incluyendo a su vez al ganado infectado como fuente de infección. Un tercer submodelo representa la contaminación del entorno con ooquistes, que actúan como fuente de infección para el ganado. Nuestro objetivo fue proporcionar una descripción más realista de la transmisión en el ganado lechero al considerar el ciclo de vida completo de N. caninum. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Laboratorio de Inmunoparasitología Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf

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