Equine keratomycosis due to Aspergillus flavus in Argentina

A 9-year-old gelding presented a corneal ulcer unresponsive to treatment in his right eye. The trauma was caused by vegetal material. The ophthalmologic exam revealed paraxial corneal opacity, whitish discharge, peripheral oedema, congestion of conjunctival vessels and corneal angiogenesis. Microsco...

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Autores principales:	Zapata, Gustavo Leonardo, Terziotti, Horacio, Tizzano, Marco Antonio, Della Vedova, Romina, Reynaldi, Francisco José
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2024
Materias:	Ciencias Veterinarias queratomicosis complejo Aspergillus flavus natamicina equino equine keratomycosis Aspergillus flavus complex natamycin
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/178264
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-178264
record_format	dspace
spelling	I19-R120-10915-1782642025-04-16T20:05:14Z http://sedici.unlp.edu.ar/handle/10915/178264 Equine keratomycosis due to Aspergillus flavus in Argentina Queratomicosis equina por Aspergillus flavus en Argentina Zapata, Gustavo Leonardo Terziotti, Horacio Tizzano, Marco Antonio Della Vedova, Romina Reynaldi, Francisco José 2024-04-11 2025-04-16T17:40:08Z en Ciencias Veterinarias queratomicosis complejo Aspergillus flavus natamicina equino equine keratomycosis Aspergillus flavus complex natamycin A 9-year-old gelding presented a corneal ulcer unresponsive to treatment in his right eye. The trauma was caused by vegetal material. The ophthalmologic exam revealed paraxial corneal opacity, whitish discharge, peripheral oedema, congestion of conjunctival vessels and corneal angiogenesis. Microscopic examination of smears revealed the presence of neutrophils and fungal hyphae. On day 3 of culture, several small white fluffy colonies that rapidly turned to pale green were detected. These colonies were isolated to study their micro and macromorphology. Microscopic examination revealed the presence of colourless, thick-walled, roughened conidiophores, ranging from 340 to 1650 μm in length, with globose to sub-globose vesicles, ranging from 22 to 48 μm in diameter. Vesicles had one or two series of phialides. Conidia were globose, olive-green with slightly rough, thin walls that ranged from 3 to 7 μm in diameter. Molecular identification was also performed. Both techniques confirmed the presence of Aspergillus flavus complex. Topical treatment with natamycin resulted in healing within 10 days. To our knowledge, this is the first case of equine keratomycosis reported in Argentina. Un equino castrado de 9 años presentó una úlcera corneal en el ojo derecho, sin respuesta al tratamiento. El trauma fue causado por material vegetal. El examen oftalmológico reveló opacidad corneal paraxial cubierta por una descarga blanquecina y edema periférico, asociado a congestión de vasos conjuntivales y angiogénesis corneal. El examen microscópico reveló la presencia de neutrófilos e hifas fúngicas. Al tercer día de cultivo se detectaron varias colonias blancas que se tornaron de color verde pálido. El examen microscópico de estos aislamientos reveló la presencia de conidióforos incoloros, rugosos y de paredes gruesas, de entre 340 y 1650 μm de longitud, con vesículas globosas a subglobosas, de entre 22 y 48 μm de diámetro. Las vesículas tenían una o dos series de fiálides. Los conidios eran globosos, de color verde oliva con paredes delgadas y ligeramente rugosas que oscilaban entre 3 y 7 μm de diámetro. También se realizó la identificación molecular. Ambas técnicas confirmaron la presencia del complejo Aspergillus flavus. El uso tópico de natamicina resultó efectivo en la resolución de la lesión. Hasta donde sabemos, este es el primer caso de queratomicosis equina reportado en Argentina. Facultad de Ciencias Veterinarias Articulo Comunicacion http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias queratomicosis complejo Aspergillus flavus natamicina equino equine keratomycosis Aspergillus flavus complex natamycin
spellingShingle	Ciencias Veterinarias queratomicosis complejo Aspergillus flavus natamicina equino equine keratomycosis Aspergillus flavus complex natamycin Zapata, Gustavo Leonardo Terziotti, Horacio Tizzano, Marco Antonio Della Vedova, Romina Reynaldi, Francisco José Equine keratomycosis due to Aspergillus flavus in Argentina
topic_facet	Ciencias Veterinarias queratomicosis complejo Aspergillus flavus natamicina equino equine keratomycosis Aspergillus flavus complex natamycin
description	A 9-year-old gelding presented a corneal ulcer unresponsive to treatment in his right eye. The trauma was caused by vegetal material. The ophthalmologic exam revealed paraxial corneal opacity, whitish discharge, peripheral oedema, congestion of conjunctival vessels and corneal angiogenesis. Microscopic examination of smears revealed the presence of neutrophils and fungal hyphae. On day 3 of culture, several small white fluffy colonies that rapidly turned to pale green were detected. These colonies were isolated to study their micro and macromorphology. Microscopic examination revealed the presence of colourless, thick-walled, roughened conidiophores, ranging from 340 to 1650 μm in length, with globose to sub-globose vesicles, ranging from 22 to 48 μm in diameter. Vesicles had one or two series of phialides. Conidia were globose, olive-green with slightly rough, thin walls that ranged from 3 to 7 μm in diameter. Molecular identification was also performed. Both techniques confirmed the presence of Aspergillus flavus complex. Topical treatment with natamycin resulted in healing within 10 days. To our knowledge, this is the first case of equine keratomycosis reported in Argentina.
format	Articulo Comunicacion
author	Zapata, Gustavo Leonardo Terziotti, Horacio Tizzano, Marco Antonio Della Vedova, Romina Reynaldi, Francisco José
author_facet	Zapata, Gustavo Leonardo Terziotti, Horacio Tizzano, Marco Antonio Della Vedova, Romina Reynaldi, Francisco José
author_sort	Zapata, Gustavo Leonardo
title	Equine keratomycosis due to Aspergillus flavus in Argentina
title_short	Equine keratomycosis due to Aspergillus flavus in Argentina
title_full	Equine keratomycosis due to Aspergillus flavus in Argentina
title_fullStr	Equine keratomycosis due to Aspergillus flavus in Argentina
title_full_unstemmed	Equine keratomycosis due to Aspergillus flavus in Argentina
title_sort	equine keratomycosis due to aspergillus flavus in argentina
publishDate	2024
url	http://sedici.unlp.edu.ar/handle/10915/178264
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Equine keratomycosis due to Aspergillus flavus in Argentina

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