Vanadis' charms: from the mithology to the bioinorganic chemistry

Vanadium is a transition element that presents a rich and varied chemical behaviour. Beyond that, vanadium compounds also show interesting biological effects both in vivo and in vitro systems. Vanadium promotes glucose transport and metabolism, lipid, DNA and protein synthesis and has also mitogenic...

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Autores principales: Etcheverry, Susana Beatriz, Ferrer, Evelina Gloria, González Baró, Ana Cecilia, Parajón Costa, Beatriz Susana, Williams, Patricia Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Química
vanadium
organic ligands
pharmacological applications
osteoblast cultures
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/177402
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-177402
record_format dspace
spelling I19-R120-10915-1774022025-03-14T20:12:06Z http://sedici.unlp.edu.ar/handle/10915/177402 Vanadis' charms: from the mithology to the bioinorganic chemistry Etcheverry, Susana Beatriz Ferrer, Evelina Gloria González Baró, Ana Cecilia Parajón Costa, Beatriz Susana Williams, Patricia Ana María 2009 2025-03-14T16:45:40Z en Química vanadium organic ligands pharmacological applications osteoblast cultures Vanadium is a transition element that presents a rich and varied chemical behaviour. Beyond that, vanadium compounds also show interesting biological effects both in vivo and in vitro systems. Vanadium promotes glucose transport and metabolism, lipid, DNA and protein synthesis and has also mitogenic effects in different cell types. Moreover, several vanadium compounds show potential pharmacological activity mainly as insulin mimics, antitumoral and osteogenic agents. Nevertheless, in large quantities it can be toxic to humans and other animals. Finally, another interesting line of research on vanadium bioactivity is the understanding of vanadium mechanisms of action. This subject is strongly related with the activation of several intracellular signalling pathways, the generation of free radicals, oxidative stress, and the disruption of cytoskeleton proteins, among others. Even though a great effort has been made by scientists in this area, a lot of work remains to be done in the future to completely elucidate the vanadium mechanisms of action. In this review, following a brief introduction about the discovery of the element and the general roles of vanadium in biological systems, we place the focus on the interactions of vanadium species with different biological and pharmacological interesting ligands as well as the effects of some vanadium compounds on cells in culture. El vanadio es un elemento de transición con ricas y variadas propiedades químicas. Además, muchos compuestos de vanadio presentan interesantes efectos biológicos tanto en sistemas in vivo como in vitro. El vanadio promueve el transporte y el metabolismo de la glucosa, la síntesis de lípidos, DNA y proteínas y presenta efectos mitogénicos en diversos tipos de células. Asimismo, numerosos compuestos de vanadio muestran potencial actividad farmacológica, en especial como agentes insulino-miméticos, antitumorales y osteogénicos. Sin embargo, en cantidades apreciables puede llegar a ser tóxico para el ser humano y otros animales. Finalmente, otra línea de investigación interesante sobre la bioactividad del vanadio es la comprensión de sus mecanismos de acción. Este tema está estrechamente relacionado con la activación de diversas señales intracelulares, la generación de radicales libres, el estrés oxidativo y la alteración de las proteínas del citoesqueleto, entre otros procesos. Aún cuando los científicos han realizado un gran esfuerzo en ese sentido, resta llevar a cabo una ardua tarea en el futuro para elucidar por completo los mecanismos de acción del vanadio. En este trabajo de revisión, a continuación de una breve introducción sobre el descubrimiento de este elemento y sus roles generales en los sistemas biológicos, se centra la atención en las interacciones del vanadio con diferentes ligandos de interés biológico o farmacológico, así como en el efecto de algunos compuestos de vanadio sobre células en cultivo. Centro de Química Inorgánica Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 127-150
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
vanadium
organic ligands
pharmacological applications
osteoblast cultures
spellingShingle Química
vanadium
organic ligands
pharmacological applications
osteoblast cultures
Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
González Baró, Ana Cecilia
Parajón Costa, Beatriz Susana
Williams, Patricia Ana María
Vanadis' charms: from the mithology to the bioinorganic chemistry
topic_facet Química
vanadium
organic ligands
pharmacological applications
osteoblast cultures
description Vanadium is a transition element that presents a rich and varied chemical behaviour. Beyond that, vanadium compounds also show interesting biological effects both in vivo and in vitro systems. Vanadium promotes glucose transport and metabolism, lipid, DNA and protein synthesis and has also mitogenic effects in different cell types. Moreover, several vanadium compounds show potential pharmacological activity mainly as insulin mimics, antitumoral and osteogenic agents. Nevertheless, in large quantities it can be toxic to humans and other animals. Finally, another interesting line of research on vanadium bioactivity is the understanding of vanadium mechanisms of action. This subject is strongly related with the activation of several intracellular signalling pathways, the generation of free radicals, oxidative stress, and the disruption of cytoskeleton proteins, among others. Even though a great effort has been made by scientists in this area, a lot of work remains to be done in the future to completely elucidate the vanadium mechanisms of action. In this review, following a brief introduction about the discovery of the element and the general roles of vanadium in biological systems, we place the focus on the interactions of vanadium species with different biological and pharmacological interesting ligands as well as the effects of some vanadium compounds on cells in culture.
format Articulo
Articulo
author Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
González Baró, Ana Cecilia
Parajón Costa, Beatriz Susana
Williams, Patricia Ana María
author_facet Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
González Baró, Ana Cecilia
Parajón Costa, Beatriz Susana
Williams, Patricia Ana María
author_sort Etcheverry, Susana Beatriz
title Vanadis' charms: from the mithology to the bioinorganic chemistry
title_short Vanadis' charms: from the mithology to the bioinorganic chemistry
title_full Vanadis' charms: from the mithology to the bioinorganic chemistry
title_fullStr Vanadis' charms: from the mithology to the bioinorganic chemistry
title_full_unstemmed Vanadis' charms: from the mithology to the bioinorganic chemistry
title_sort vanadis' charms: from the mithology to the bioinorganic chemistry
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/177402
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AT gonzalezbaroanacecilia vanadischarmsfromthemithologytothebioinorganicchemistry
AT parajoncostabeatrizsusana vanadischarmsfromthemithologytothebioinorganicchemistry
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