Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides

A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzod...

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Autores principales: Sasiambarrena, Leandro Daniel, Barri, Iván Alejandro, Fraga, Guido Gustavo, Bravo, Rodolfo Daniel, Ponzinibbio, Agustín
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Química
1,4-Benzodiazepines
2-Chloro-N-(2-nitrobenzyl)acetamides
Iron-ammonium chloride reduction
2-Nitrobenzylamines
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/172505
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-172505
record_format dspace
spelling I19-R120-10915-1725052024-11-04T20:10:38Z http://sedici.unlp.edu.ar/handle/10915/172505 Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides Sasiambarrena, Leandro Daniel Barri, Iván Alejandro Fraga, Guido Gustavo Bravo, Rodolfo Daniel Ponzinibbio, Agustín 2018-12-14 2024-11-04T15:58:28Z en Química 1,4-Benzodiazepines 2-Chloro-N-(2-nitrobenzyl)acetamides Iron-ammonium chloride reduction 2-Nitrobenzylamines A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research. Centro de Estudios de Compuestos Orgánicos Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
1,4-Benzodiazepines
2-Chloro-N-(2-nitrobenzyl)acetamides
Iron-ammonium chloride reduction
2-Nitrobenzylamines
spellingShingle Química
1,4-Benzodiazepines
2-Chloro-N-(2-nitrobenzyl)acetamides
Iron-ammonium chloride reduction
2-Nitrobenzylamines
Sasiambarrena, Leandro Daniel
Barri, Iván Alejandro
Fraga, Guido Gustavo
Bravo, Rodolfo Daniel
Ponzinibbio, Agustín
Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
topic_facet Química
1,4-Benzodiazepines
2-Chloro-N-(2-nitrobenzyl)acetamides
Iron-ammonium chloride reduction
2-Nitrobenzylamines
description A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.
format Articulo
Articulo
author Sasiambarrena, Leandro Daniel
Barri, Iván Alejandro
Fraga, Guido Gustavo
Bravo, Rodolfo Daniel
Ponzinibbio, Agustín
author_facet Sasiambarrena, Leandro Daniel
Barri, Iván Alejandro
Fraga, Guido Gustavo
Bravo, Rodolfo Daniel
Ponzinibbio, Agustín
author_sort Sasiambarrena, Leandro Daniel
title Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
title_short Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
title_full Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
title_fullStr Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
title_full_unstemmed Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
title_sort facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-n-(2-nitrobenzyl)acetamides
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/172505
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