New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)

In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic vol...

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Detalles Bibliográficos
Autores principales: Lobo Maza, Flavia Emilia, Méndez De Leo, Lucila, Rubert, Aldo Alberto, Carro, Pilar, Salvarezza, Roberto Carlos, Vericat, Carolina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/170143
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-170143
record_format dspace
spelling I19-R120-10915-1701432024-09-14T04:08:46Z http://sedici.unlp.edu.ar/handle/10915/170143 New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111) Lobo Maza, Flavia Emilia Méndez De Leo, Lucila Rubert, Aldo Alberto Carro, Pilar Salvarezza, Roberto Carlos Vericat, Carolina 2016 2024-09-13T15:00:25Z en Química gold Metal nanoparticles Molecules Solution chemistry Thiols In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 14597-14607
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
spellingShingle Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
Lobo Maza, Flavia Emilia
Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
topic_facet Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
description In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface.
format Articulo
Articulo
author Lobo Maza, Flavia Emilia
Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
author_facet Lobo Maza, Flavia Emilia
Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
author_sort Lobo Maza, Flavia Emilia
title New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_short New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_full New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_fullStr New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_full_unstemmed New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_sort new insight into the interface chemistry and stability of glutathione self-assembled monolayers on au(111)
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/170143
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