In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves

Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used...

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Detalles Bibliográficos
Autores principales: Hugo, Ayelén Amelia, Serradell, María de los Ángeles, Peri, Pablo, Farina, Sebastián, Gómez-Zavaglia, Andrea
Formato: Articulo
Lenguaje:Inglés
Publicado: 2024
Materias:
Química
Biología
Animal model
antioxidant activity
ñire
Nothofagus antarctica
toxicity
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/167379
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-167379
record_format dspace
spelling I19-R120-10915-1673792024-06-19T20:09:01Z http://sedici.unlp.edu.ar/handle/10915/167379 In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves Hugo, Ayelén Amelia Serradell, María de los Ángeles Peri, Pablo Farina, Sebastián Gómez-Zavaglia, Andrea 2024 2024-06-19T12:55:18Z en Química Biología Animal model antioxidant activity ñire Nothofagus antarctica toxicity Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress. Facultad de Ciencias Exactas Centro de Investigación y Desarrollo en Criotecnología de Alimentos Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Biología
Animal model
antioxidant activity
ñire
Nothofagus antarctica
toxicity
spellingShingle Química
Biología
Animal model
antioxidant activity
ñire
Nothofagus antarctica
toxicity
Hugo, Ayelén Amelia
Serradell, María de los Ángeles
Peri, Pablo
Farina, Sebastián
Gómez-Zavaglia, Andrea
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
topic_facet Química
Biología
Animal model
antioxidant activity
ñire
Nothofagus antarctica
toxicity
description Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress.
format Articulo
Articulo
author Hugo, Ayelén Amelia
Serradell, María de los Ángeles
Peri, Pablo
Farina, Sebastián
Gómez-Zavaglia, Andrea
author_facet Hugo, Ayelén Amelia
Serradell, María de los Ángeles
Peri, Pablo
Farina, Sebastián
Gómez-Zavaglia, Andrea
author_sort Hugo, Ayelén Amelia
title In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_short In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_full In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_fullStr In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_full_unstemmed In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
title_sort in vivo oral toxicity and antioxidant capacity of nothofagus antarctica (g.forst.) oerst (ñire) leaves
publishDate 2024
url http://sedici.unlp.edu.ar/handle/10915/167379
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