Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery

Risperidone is an antipsychotic commonly used during pregnancy. Because it can cross the placental barrier, our objective was to evaluate its actions on the smooth muscle of the human umbilical artery (HUA). Risperidone preincubation (1-300 nmol/L for 20 minutes) produced a significant decrease in m...

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Autores principales: Iveli, María Florencia, Rebolledo, Alejandro, Martín, Pedro, Enrique, Nicolás Jorge, Roldán Palomo, Ana Rocío, Rimorini, Laura, Salemme, Silvia Verónica, Milesi, María Verónica
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Exactas
Human umbilical artery
risperidone
serotonin
histamine
potassium channels
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/167269
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-167269
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spelling I19-R120-10915-1672692024-06-15T04:07:41Z http://sedici.unlp.edu.ar/handle/10915/167269 Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery Iveli, María Florencia Rebolledo, Alejandro Martín, Pedro Enrique, Nicolás Jorge Roldán Palomo, Ana Rocío Rimorini, Laura Salemme, Silvia Verónica Milesi, María Verónica 2010 2024-06-14T15:07:31Z en Ciencias Exactas Human umbilical artery risperidone serotonin histamine potassium channels Risperidone is an antipsychotic commonly used during pregnancy. Because it can cross the placental barrier, our objective was to evaluate its actions on the smooth muscle of the human umbilical artery (HUA). Risperidone preincubation (1-300 nmol/L for 20 minutes) produced a significant decrease in maximum force development induced by serotonin or histamine inHUArings. When applied on top of stable contractions induced by these agonists risperidone produced quick relaxations (IC50 ¼ 1 nmol/L for serotonin and 72 nmol/L for histamine). Risperidone induced the contraction of vascular rings depolarized by 40 mmol/L extracellular Kþ but not in the case of 80 mmol/LKþ, suggesting inhibition of Kþ channels. The patch-clamp technique showed that risperidone (3 nmol/L) inhibited whole-cell Kþ currents in freshly isolated HUA smooth muscle cells. Our results are the first showing risperidone effects in human vascular smooth muscle and highlight that its use during pregnancy should be adequately monitored. Facultad de Ciencias Exactas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 854-860
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Human umbilical artery
risperidone
serotonin
histamine
potassium channels
spellingShingle Ciencias Exactas
Human umbilical artery
risperidone
serotonin
histamine
potassium channels
Iveli, María Florencia
Rebolledo, Alejandro
Martín, Pedro
Enrique, Nicolás Jorge
Roldán Palomo, Ana Rocío
Rimorini, Laura
Salemme, Silvia Verónica
Milesi, María Verónica
Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
topic_facet Ciencias Exactas
Human umbilical artery
risperidone
serotonin
histamine
potassium channels
description Risperidone is an antipsychotic commonly used during pregnancy. Because it can cross the placental barrier, our objective was to evaluate its actions on the smooth muscle of the human umbilical artery (HUA). Risperidone preincubation (1-300 nmol/L for 20 minutes) produced a significant decrease in maximum force development induced by serotonin or histamine inHUArings. When applied on top of stable contractions induced by these agonists risperidone produced quick relaxations (IC50 ¼ 1 nmol/L for serotonin and 72 nmol/L for histamine). Risperidone induced the contraction of vascular rings depolarized by 40 mmol/L extracellular Kþ but not in the case of 80 mmol/LKþ, suggesting inhibition of Kþ channels. The patch-clamp technique showed that risperidone (3 nmol/L) inhibited whole-cell Kþ currents in freshly isolated HUA smooth muscle cells. Our results are the first showing risperidone effects in human vascular smooth muscle and highlight that its use during pregnancy should be adequately monitored.
format Articulo
Articulo
author Iveli, María Florencia
Rebolledo, Alejandro
Martín, Pedro
Enrique, Nicolás Jorge
Roldán Palomo, Ana Rocío
Rimorini, Laura
Salemme, Silvia Verónica
Milesi, María Verónica
author_facet Iveli, María Florencia
Rebolledo, Alejandro
Martín, Pedro
Enrique, Nicolás Jorge
Roldán Palomo, Ana Rocío
Rimorini, Laura
Salemme, Silvia Verónica
Milesi, María Verónica
author_sort Iveli, María Florencia
title Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
title_short Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
title_full Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
title_fullStr Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
title_full_unstemmed Risperidone Inhibits Contractions Induced by Serotonin and Histamine and Reduces Kþ Currents in Smooth Muscle of Human Umbilical Artery
title_sort risperidone inhibits contractions induced by serotonin and histamine and reduces kþ currents in smooth muscle of human umbilical artery
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/167269
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