Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties

Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differe...

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Autores principales: Pasqualone, Magalí, Oberti, Tamara Gisela, Andreetta, Héctor Alfredo, Cortizo, María Susana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/164159
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-164159
record_format dspace
spelling I19-R120-10915-1641592024-03-22T20:10:08Z http://sedici.unlp.edu.ar/handle/10915/164159 Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties Pasqualone, Magalí Oberti, Tamara Gisela Andreetta, Héctor Alfredo Cortizo, María Susana 2013-07 2024-03-22T17:28:38Z en Ciencias Exactas Química fumarate risedronate vinyl acetate water absorption capacity Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 1683-1692
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
spellingShingle Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
topic_facet Ciencias Exactas
Química
fumarate
risedronate
vinyl acetate
water absorption capacity
description Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by ¹H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
format Articulo
Articulo
author Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
author_facet Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, María Susana
author_sort Pasqualone, Magalí
title Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_short Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_full Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_fullStr Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_full_unstemmed Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
title_sort fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/164159
work_keys_str_mv AT pasqualonemagali fumaratecopolymersbasedmembranesoverlookingfuturetransdermaldeliverydevicessynthesisandproperties
AT obertitamaragisela fumaratecopolymersbasedmembranesoverlookingfuturetransdermaldeliverydevicessynthesisandproperties
AT andreettahectoralfredo fumaratecopolymersbasedmembranesoverlookingfuturetransdermaldeliverydevicessynthesisandproperties
AT cortizomariasusana fumaratecopolymersbasedmembranesoverlookingfuturetransdermaldeliverydevicessynthesisandproperties
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