Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies

This article presents the preparation of matrices from two new families of fumaric copolymers and the effect of structural differences on their physicochemical and biological behavior. Diisopropyl fumarate (DIPF) and poly(ethylene glycol) methyl ether methacrylate (OEGMA) or N-isopropylacrylamide (N...

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Autores principales: Bravi Costantino, Maria Leticia, Oberti, Tamara Gisela, Cortizo, Ana María, Cortizo, María Susana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Química
Biología
fumaric copolymer
RAFT polymerization
thermal properties
cytotoxicity
biocompatibility
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/164092
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-164092
record_format dspace
spelling I19-R120-10915-1640922024-03-21T20:09:32Z http://sedici.unlp.edu.ar/handle/10915/164092 Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies Bravi Costantino, Maria Leticia Oberti, Tamara Gisela Cortizo, Ana María Cortizo, María Susana 2019-01 2024-03-21T13:31:27Z en Química Biología fumaric copolymer RAFT polymerization thermal properties cytotoxicity biocompatibility This article presents the preparation of matrices from two new families of fumaric copolymers and the effect of structural differences on their physicochemical and biological behavior. Diisopropyl fumarate (DIPF) and poly(ethylene glycol) methyl ether methacrylate (OEGMA) or N-isopropylacrylamide (NIPAM) were copolymerized by conventional radical and RAFT polymerization to obtain lineal or start architectures, respectively. These copolymers were characterized by spectroscopic (FTIR and ¹HNMR) and chromatographic methods. The thermal stability was studied by thermal gravimetric analysis, showing some differences in relation to the architecture and chemical nature of copolymers. SEM morphological analysis demonstrated that the surface of the matrices derived from OEGMA exhibited an irregular and rough surface, while DIPF–NIPAM copolymers presented smooth surface with nearly no significant porosity. The matrix obtained of both kinds of copolymers presented no cytotoxicity as it was evaluated using a model of macrophages on culture. Moreover, cell growth was better on the surfaces of the DIPF–NIPAM matrices, suggesting a good interaction with this matrix and its potential application as matrices for tissue engineering. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Laboratorio de Investigación en Osteopatías y Metabolismo Mineral Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 195-203
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Biología
fumaric copolymer
RAFT polymerization
thermal properties
cytotoxicity
biocompatibility
spellingShingle Química
Biología
fumaric copolymer
RAFT polymerization
thermal properties
cytotoxicity
biocompatibility
Bravi Costantino, Maria Leticia
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
topic_facet Química
Biología
fumaric copolymer
RAFT polymerization
thermal properties
cytotoxicity
biocompatibility
description This article presents the preparation of matrices from two new families of fumaric copolymers and the effect of structural differences on their physicochemical and biological behavior. Diisopropyl fumarate (DIPF) and poly(ethylene glycol) methyl ether methacrylate (OEGMA) or N-isopropylacrylamide (NIPAM) were copolymerized by conventional radical and RAFT polymerization to obtain lineal or start architectures, respectively. These copolymers were characterized by spectroscopic (FTIR and ¹HNMR) and chromatographic methods. The thermal stability was studied by thermal gravimetric analysis, showing some differences in relation to the architecture and chemical nature of copolymers. SEM morphological analysis demonstrated that the surface of the matrices derived from OEGMA exhibited an irregular and rough surface, while DIPF–NIPAM copolymers presented smooth surface with nearly no significant porosity. The matrix obtained of both kinds of copolymers presented no cytotoxicity as it was evaluated using a model of macrophages on culture. Moreover, cell growth was better on the surfaces of the DIPF–NIPAM matrices, suggesting a good interaction with this matrix and its potential application as matrices for tissue engineering.
format Articulo
Articulo
author Bravi Costantino, Maria Leticia
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
author_facet Bravi Costantino, Maria Leticia
Oberti, Tamara Gisela
Cortizo, Ana María
Cortizo, María Susana
author_sort Bravi Costantino, Maria Leticia
title Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
title_short Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
title_full Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
title_fullStr Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
title_full_unstemmed Matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: Characterization and biocompatibility studies
title_sort matrices based on lineal and star fumarate-metha/acrylate copolymers for bone tissue engineering: characterization and biocompatibility studies
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/164092
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