CaMKII: cardiac physiological functions

Calcium-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr kinase whose activity is triggered by calcium (Ca2+), in response to various distinct signaling pathways in different organs, including the pancreas, liver, brain, and heart. CaMKII was discovered in the late sixties. Interestingly, t...

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Autores principales: Valverde, Carlos Alfredo, Said, María Matilde, Mundiña-Weilenmann, Cecilia, Mattiazzi, Alicia Ramona
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Ciencias Médicas
Biología
cardiac physiology
calcium-calmodulin
protein kinase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/163683
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-163683
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spelling I19-R120-10915-1636832024-03-11T20:04:32Z http://sedici.unlp.edu.ar/handle/10915/163683 CaMKII: cardiac physiological functions Valverde, Carlos Alfredo Said, María Matilde Mundiña-Weilenmann, Cecilia Mattiazzi, Alicia Ramona 2023-12 2024-03-11T17:47:46Z en Ciencias Médicas Biología cardiac physiology calcium-calmodulin protein kinase Calcium-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr kinase whose activity is triggered by calcium (Ca2+), in response to various distinct signaling pathways in different organs, including the pancreas, liver, brain, and heart. CaMKII was discovered in the late sixties. Interestingly, the initial mentions of this kinase were nearly simultaneous in both the brain and the heart, despite it is more abundant in the brain, where it plays a crucial role in memory and learning processes. CaMKII is unique in that it is very widely distributed and can phosphorylate a broad range of proteins. These properties promptly suggested that CaMKII regulates many physiological responses to agonists that elevate intracellular Ca2+, leading to its designation as the "multifunctional Ca/CaM-dependent protein kinase" or "CaM-dependent multiprotein kinase". Encoded by four different genes (α, β, γ, and δ), CaMKIIδ is the predominant isoform in the heart, with two splice variants in the adult myocardium: δB, mainly localized in the nucleus, and δC, primarily found in the cytosol. Given its role in phosphorylating proteins related to Ca2+ handling and excitation-contraction coupling (ECC), CaMKII is believed to play an important role in physiological processes. However, unlike its well-established role in memory and learning, the physiological significance of CaMKII on cardiac function is less acknowledged. Indeed, its better-known associations lie in non-physiological actions within the heart, particularly in various cardiac pathologies such as heart failure (HF), myocardial infarction, and cardiomyopathies, leading to contractile dysfunction and malignant arrhythmias. This mini review aims to provide a concise summary of CaMKII's role on cardiac physiology. Sociedad Argentina de Fisiología Centro de Investigaciones Cardiovasculares Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Biología
cardiac physiology
calcium-calmodulin
protein kinase
spellingShingle Ciencias Médicas
Biología
cardiac physiology
calcium-calmodulin
protein kinase
Valverde, Carlos Alfredo
Said, María Matilde
Mundiña-Weilenmann, Cecilia
Mattiazzi, Alicia Ramona
CaMKII: cardiac physiological functions
topic_facet Ciencias Médicas
Biología
cardiac physiology
calcium-calmodulin
protein kinase
description Calcium-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr kinase whose activity is triggered by calcium (Ca2+), in response to various distinct signaling pathways in different organs, including the pancreas, liver, brain, and heart. CaMKII was discovered in the late sixties. Interestingly, the initial mentions of this kinase were nearly simultaneous in both the brain and the heart, despite it is more abundant in the brain, where it plays a crucial role in memory and learning processes. CaMKII is unique in that it is very widely distributed and can phosphorylate a broad range of proteins. These properties promptly suggested that CaMKII regulates many physiological responses to agonists that elevate intracellular Ca2+, leading to its designation as the "multifunctional Ca/CaM-dependent protein kinase" or "CaM-dependent multiprotein kinase". Encoded by four different genes (α, β, γ, and δ), CaMKIIδ is the predominant isoform in the heart, with two splice variants in the adult myocardium: δB, mainly localized in the nucleus, and δC, primarily found in the cytosol. Given its role in phosphorylating proteins related to Ca2+ handling and excitation-contraction coupling (ECC), CaMKII is believed to play an important role in physiological processes. However, unlike its well-established role in memory and learning, the physiological significance of CaMKII on cardiac function is less acknowledged. Indeed, its better-known associations lie in non-physiological actions within the heart, particularly in various cardiac pathologies such as heart failure (HF), myocardial infarction, and cardiomyopathies, leading to contractile dysfunction and malignant arrhythmias. This mini review aims to provide a concise summary of CaMKII's role on cardiac physiology.
format Articulo
Articulo
author Valverde, Carlos Alfredo
Said, María Matilde
Mundiña-Weilenmann, Cecilia
Mattiazzi, Alicia Ramona
author_facet Valverde, Carlos Alfredo
Said, María Matilde
Mundiña-Weilenmann, Cecilia
Mattiazzi, Alicia Ramona
author_sort Valverde, Carlos Alfredo
title CaMKII: cardiac physiological functions
title_short CaMKII: cardiac physiological functions
title_full CaMKII: cardiac physiological functions
title_fullStr CaMKII: cardiac physiological functions
title_full_unstemmed CaMKII: cardiac physiological functions
title_sort camkii: cardiac physiological functions
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/163683
work_keys_str_mv AT valverdecarlosalfredo camkiicardiacphysiologicalfunctions
AT saidmariamatilde camkiicardiacphysiologicalfunctions
AT mundinaweilenmanncecilia camkiicardiacphysiologicalfunctions
AT mattiazzialiciaramona camkiicardiacphysiologicalfunctions
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