Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones
We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably incr...
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2012
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/163622 |
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I19-R120-10915-1636222024-03-08T20:10:01Z http://sedici.unlp.edu.ar/handle/10915/163622 Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones D'Alessandro, Oriana Sathicq, Ángel Gabriel Sánchez, Laura Mabel Thomas, Horacio Jorge Vázquez, Patricia Graciela Constantieux, T. Romanelli, Gustavo Pablo 2012 2024-03-08T18:26:08Z en Ingeniería Química 3,4-Dihydropyrimidin-2-(1 H)-ones Biginelli reaction modified Keggin heteropolyacids solvent-free synthesis We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably increases the catalytic activity. The following correlation between the yields of the 3,4-dihydropyrimidin-2-(1H)-ones and the number of acidic sites of the catalysts was observed: PMoBiV > PMoV > PMoBi > PMo. The re action experiments were performed in the absence of solvent, at 80ºC (1 h). Under these conditions and using the most active catalyst (PMoBiV), twelve examples were obtained with very good yields (80%–98%) and high selectivity. The catalyst was easily recycled and reused without appreciable loss of its catalytic activity. The synthetic method presented is a simple, clean and environmentally friendly alternative for the obtention of substituted 3,4-dihydropyrimidin-2-(1H)-ones. Centro de Investigación y Desarrollo en Tecnología de Pinturas Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ingeniería Química 3,4-Dihydropyrimidin-2-(1 H)-ones Biginelli reaction modified Keggin heteropolyacids solvent-free synthesis |
| spellingShingle |
Ingeniería Química 3,4-Dihydropyrimidin-2-(1 H)-ones Biginelli reaction modified Keggin heteropolyacids solvent-free synthesis D'Alessandro, Oriana Sathicq, Ángel Gabriel Sánchez, Laura Mabel Thomas, Horacio Jorge Vázquez, Patricia Graciela Constantieux, T. Romanelli, Gustavo Pablo Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| topic_facet |
Ingeniería Química 3,4-Dihydropyrimidin-2-(1 H)-ones Biginelli reaction modified Keggin heteropolyacids solvent-free synthesis |
| description |
We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably increases the catalytic activity. The following correlation between the yields of the 3,4-dihydropyrimidin-2-(1H)-ones and the number of acidic sites of the catalysts was observed: PMoBiV > PMoV > PMoBi > PMo. The re action experiments were performed in the absence of solvent, at 80ºC (1 h). Under these conditions and using the most active catalyst (PMoBiV), twelve examples were obtained with very good yields (80%–98%) and high selectivity. The catalyst was easily recycled and reused without appreciable loss of its catalytic activity. The synthetic method presented is a simple, clean and environmentally friendly alternative for the obtention of substituted 3,4-dihydropyrimidin-2-(1H)-ones. |
| format |
Articulo Articulo |
| author |
D'Alessandro, Oriana Sathicq, Ángel Gabriel Sánchez, Laura Mabel Thomas, Horacio Jorge Vázquez, Patricia Graciela Constantieux, T. Romanelli, Gustavo Pablo |
| author_facet |
D'Alessandro, Oriana Sathicq, Ángel Gabriel Sánchez, Laura Mabel Thomas, Horacio Jorge Vázquez, Patricia Graciela Constantieux, T. Romanelli, Gustavo Pablo |
| author_sort |
D'Alessandro, Oriana |
| title |
Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| title_short |
Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| title_full |
Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| title_fullStr |
Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| title_full_unstemmed |
Doped Keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 H)-ones |
| title_sort |
doped keggin heteropolyacids as catalyst in the solvent-free, multicomponent synthesis of substituted 3,4-dihydropyrimidin-2(1 h)-ones |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/163622 |
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