Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions
In past decades, adipose tissue was considered as a mere fat deposit and therefore an energy storage. Nowadays, we know that, by secreting endocrine and paracrine factors, it plays a major role in regulating metabolism and homeostasis. Therefore, from the physiological point of view it is considered...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/163602 |
| Aporte de: |
| Sumario: | In past decades, adipose tissue was considered as a mere fat deposit and therefore an energy storage. Nowadays, we know that, by secreting endocrine and paracrine factors, it plays a major role in regulating metabolism and homeostasis. Therefore, from the physiological point of view it is considered as an endocrine organ. Adipose tissue is target of insulin action, which promotes the uptake and storage of glucose in the form of fatty acids. In cardiovascular diseases such as high blood pressure, the response to insulin and the metabolism of adipose tissue are altered. It has been demonstrated that the blocking of the renin-angiotensin-aldosterone system (RAAS) is effective in counteracting those alterations. On the other hand, aerobic exercise has been shown to be a useful tool to modify the adipose tissue, alterations observed in cardiovascular diseases. Exercise changes the phenotype of adipose tissue from white to beige with the consequent improvement in the response to insulin at the systemic level. Recently, it has been proposed that the RAAS, through an increase in the hypotensive arm, could mediate the beneficial effects of exercise on adipose tissue, and favor the development of the beige phenotype of this tissue. In this review we will focus on the interaction of adipose tissue, RAAS and aerobic training in a context of arterial hypertension and insulin resistance. |
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