Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions
In past decades, adipose tissue was considered as a mere fat deposit and therefore an energy storage. Nowadays, we know that, by secreting endocrine and paracrine factors, it plays a major role in regulating metabolism and homeostasis. Therefore, from the physiological point of view it is considered...
| Autores principales: | , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2023
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/163602 |
| Aporte de: |
| id |
I19-R120-10915-163602 |
|---|---|
| record_format |
dspace |
| spelling |
I19-R120-10915-1636022024-03-08T20:03:30Z http://sedici.unlp.edu.ar/handle/10915/163602 Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions Cavalli, Fiorella A. Caldiz, Claudia Irma 2023-02 2024-03-08T16:54:27Z en Ciencias Médicas adipose tissue insulin resistance hypertension Renin-Angiotensin-Aldosterone-System tejido adiposo resistencia a la insulina hipertensión Sistema Renina, Angiotensina, Aldosterona RAAS In past decades, adipose tissue was considered as a mere fat deposit and therefore an energy storage. Nowadays, we know that, by secreting endocrine and paracrine factors, it plays a major role in regulating metabolism and homeostasis. Therefore, from the physiological point of view it is considered as an endocrine organ. Adipose tissue is target of insulin action, which promotes the uptake and storage of glucose in the form of fatty acids. In cardiovascular diseases such as high blood pressure, the response to insulin and the metabolism of adipose tissue are altered. It has been demonstrated that the blocking of the renin-angiotensin-aldosterone system (RAAS) is effective in counteracting those alterations. On the other hand, aerobic exercise has been shown to be a useful tool to modify the adipose tissue, alterations observed in cardiovascular diseases. Exercise changes the phenotype of adipose tissue from white to beige with the consequent improvement in the response to insulin at the systemic level. Recently, it has been proposed that the RAAS, through an increase in the hypotensive arm, could mediate the beneficial effects of exercise on adipose tissue, and favor the development of the beige phenotype of this tissue. In this review we will focus on the interaction of adipose tissue, RAAS and aerobic training in a context of arterial hypertension and insulin resistance. En décadas pasadas, el tejido adiposo ha sido considerado como un mero depósito de grasa y como un órgano de almacenamiento de energía. Hoy en día sabemos que, a través de la secreción de factores endócrinos y parácrinos, éste tejido juega un papel importante en la regulación del metabolismo y la homeostasis. Por lo tanto desde el punto de vista fisiológico se considera al tejido adiposo como un órgano endócrino. El tejido adiposo es blanco de acción de la insulina, promoviendo ésta la captación y el almacenamiento de glucosa en forma de ácidos grasos. En enfermedades cardiovasculares como hipertensión arterial la respuesta a insulina y el metabolismo del tejido adiposo se encuentran alterados. Se ha visto que el bloqueo del sistema renina-angiotensina-aldosterona (RAAS) resulta efectivo para contrarrestar estas alteraciones. Por otra parte, el ejercicio aeróbico ha demostrado ser una herramienta útil para modificar las alteraciones metabólicas del tejido adiposo que se observan en individuos con enfermedades cardiovasculares. Estas modificaciones involucran el cambio de fenotipo del tejido adiposo de blanco a beige con la consecuente mejora en la respuesta a la insulina a nivel sistémico. En este último tiempo se ha propuesto que el RAAS, a través de un aumento en la actividad del brazo hipotensor, podría mediar los efectos benéficos del ejercicio sobre el tejido adiposo, favoreciendo el desarrollo del fenotipo beige de este tejido. En esta revisión se abordará la relación entre tejido adiposo, RAAS y entrenamiento aeróbico en un contexto de hipertensión arterial y resistencia a la insulina. Sociedad Argentina de Fisiología Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 1-9 |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas adipose tissue insulin resistance hypertension Renin-Angiotensin-Aldosterone-System tejido adiposo resistencia a la insulina hipertensión Sistema Renina, Angiotensina, Aldosterona RAAS |
| spellingShingle |
Ciencias Médicas adipose tissue insulin resistance hypertension Renin-Angiotensin-Aldosterone-System tejido adiposo resistencia a la insulina hipertensión Sistema Renina, Angiotensina, Aldosterona RAAS Cavalli, Fiorella A. Caldiz, Claudia Irma Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| topic_facet |
Ciencias Médicas adipose tissue insulin resistance hypertension Renin-Angiotensin-Aldosterone-System tejido adiposo resistencia a la insulina hipertensión Sistema Renina, Angiotensina, Aldosterona RAAS |
| description |
In past decades, adipose tissue was considered as a mere fat deposit and therefore an energy storage. Nowadays, we know that, by secreting endocrine and paracrine factors, it plays a major role in regulating metabolism and homeostasis. Therefore, from the physiological point of view it is considered as an endocrine organ. Adipose tissue is target of insulin action, which promotes the uptake and storage of glucose in the form of fatty acids. In cardiovascular diseases such as high blood pressure, the response to insulin and the metabolism of adipose tissue are altered. It has been demonstrated that the blocking of the renin-angiotensin-aldosterone system (RAAS) is effective in counteracting those alterations. On the other hand, aerobic exercise has been shown to be a useful tool to modify the adipose tissue, alterations observed in cardiovascular diseases. Exercise changes the phenotype of adipose tissue from white to beige with the consequent improvement in the response to insulin at the systemic level. Recently, it has been proposed that the RAAS, through an increase in the hypotensive arm, could mediate the beneficial effects of exercise on adipose tissue, and favor the development of the beige phenotype of this tissue. In this review we will focus on the interaction of adipose tissue, RAAS and aerobic training in a context of arterial hypertension and insulin resistance. |
| format |
Articulo Articulo |
| author |
Cavalli, Fiorella A. Caldiz, Claudia Irma |
| author_facet |
Cavalli, Fiorella A. Caldiz, Claudia Irma |
| author_sort |
Cavalli, Fiorella A. |
| title |
Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| title_short |
Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| title_full |
Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| title_fullStr |
Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| title_full_unstemmed |
Past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| title_sort |
past, present and future perspectives of adipose tissue, exercise and renin-angiotensin-aldosterone system interactions |
| publishDate |
2023 |
| url |
http://sedici.unlp.edu.ar/handle/10915/163602 |
| work_keys_str_mv |
AT cavallifiorellaa pastpresentandfutureperspectivesofadiposetissueexerciseandreninangiotensinaldosteronesysteminteractions AT caldizclaudiairma pastpresentandfutureperspectivesofadiposetissueexerciseandreninangiotensinaldosteronesysteminteractions |
| _version_ |
1807222617120178176 |