Self-sterilizing ormosils surfaces based on photo-synzthesized silver nanoparticles

Medical device-related infections represent a major healthcare complication, resulting in potential risks for the patient. Antimicrobial materials comprise an attractive strategy against bacterial colonization and biofilm proliferation. However, in most cases these materials are only bacteriostatic...

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Detalles Bibliográficos
Autores principales: Gonçalves, Lidiane Patricia, Miñán, Alejandro Guillermo, Benitez, Guillermo Alfredo, Fernández Lorenzo de Mele, Mónica Alicia, Vela, María Elena, Schilardi, Patricia Laura, Ferreira Neto, Elias Paiva, Noveletto, Júlia Cristina, Correr, Wagner Rafael, Pereira Rodrigues-Filho, Ubirajara
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Exactas
Química
antibacterial activity
Pseudomonas aeruginosa
Staphylococcus aureus
ormosil
Ag nanoparticles
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/163488
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Medical device-related infections represent a major healthcare complication, resulting in potential risks for the patient. Antimicrobial materials comprise an attractive strategy against bacterial colonization and biofilm proliferation. However, in most cases these materials are only bacteriostatic or bactericidal, and consequently they must be used in combination with other antimicrobials in order to reach the eradication condition (no viable microorganisms). In this study, a straightforward and robust antibacterial coating based on Phosphotungstate Ormosil doped with core-shell (SiO₂@TiO₂) was developed using sol-gel process, chemical tempering, and Ag nanoparticle photoassisted synthesis (POrs-CS-Ag). The coating was characterized by X-ray Fluorescence Spectroscopy (XRF), Field Emission Scanning Electron Microscopy (FE-SEM), Atomic Force Microscopy (AFM) and X-ray Photoelectron Microscopy (XPS). The silver free coating displays low antibacterial activity against "Staphylococcus aureus" and "Pseudomonas aeruginosa", in opposition to the silver loaded ones, which are able to completely eradicate these strains. Moreover, the antimicrobial activity of these substrates remains high until three reutilization cycles, which make them a promising strategy to develop self-sterilizing materials, such as POrs-CS-Ag-impregnated fabric, POrs-CS-Ag coated indwelling metals and polymers, among other materials.

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