The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease

The Calcium/Calmodulin-dependent protein kinase II (CaMKII) is a versatile signaling protein involved in many cellular processes. It is considered a promising therapeutic target for cardiovascular disease. CaMKII is uniquely capable of integrating various upstream signaling inputs, including redox s...

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Autor principal: Wang, Qinchuan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Bioquímica
CaMKII
redox signal
evolutionary trade-off
señales redox
compensación evolutiva
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/162884
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SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-162884
record_format dspace
spelling I19-R120-10915-1628842024-02-20T20:02:59Z http://sedici.unlp.edu.ar/handle/10915/162884 The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease Wang, Qinchuan 2022-10 2024-02-20T12:28:35Z en Bioquímica CaMKII redox signal evolutionary trade-off señales redox compensación evolutiva The Calcium/Calmodulin-dependent protein kinase II (CaMKII) is a versatile signaling protein involved in many cellular processes. It is considered a promising therapeutic target for cardiovascular disease. CaMKII is uniquely capable of integrating various upstream signaling inputs, including redox signals, to regulate a wide range of downstream targets. The activation of CaMKII through the oxidation of a pair of oxidant-sensitive residues in its autoinhibitory region has been established as a significant driver of diseases. However, recent findings suggest that this oxidative activation mechanism is highly conserved and plays critical physiological roles. CaMKII oxidation, thus, is an example of evolutionary trade-offs that confer fitness benefits but also increase disease susceptibility. Understanding how CaMKII oxidation is regulated, and what downstream targets are regulated by oxidized CaMKII will help enhance the benefits while minimizing the detriments of this double-edged sword. La proteína quinasa dependiente de Ca y calmodulina II (CaMKII) es una proteína de señalización versátil involucrada en muchos procesos celulares y es considera un prometedor blanco terapéutico para la enfermedad cardiaca. La CaMKII es única en cuanto es capaz de integrar diversas vías de señalización rio arriba, incluidas señales redox, para regular diversos blancos rio abajo. La activación de CaMKII a través de la oxidación de un par de residuos sensibles a la oxidación en su región auto inhibitoria, constituye un factor importante en el desencadenamiento de enfermedades. Sin embargo, estudios recientes sugieren que el mecanismo de activación por oxidación es un mecanismo altamente conservado que juega roles fisiológicos críticos. La oxidación de la CaMKII es, es en realidad un ejemplo de compensaciones evolutivas que son beneficiosos pero que también aumenta la susceptibilidad a la enfermedad. La comprensión de cómo se regula la oxidación de la CaMKII y de cuáles blancos corriente abajo son regulados por la oxidación de la CaMKII, ayudara a aumentar los efectos beneficiosos de esta kinasa al mismo tiempo que a minimizar sus efectos adversos. Sociedad Argentina de Fisiología Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 61-69
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
CaMKII
redox signal
evolutionary trade-off
señales redox
compensación evolutiva
spellingShingle Bioquímica
CaMKII
redox signal
evolutionary trade-off
señales redox
compensación evolutiva
Wang, Qinchuan
The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
topic_facet Bioquímica
CaMKII
redox signal
evolutionary trade-off
señales redox
compensación evolutiva
description The Calcium/Calmodulin-dependent protein kinase II (CaMKII) is a versatile signaling protein involved in many cellular processes. It is considered a promising therapeutic target for cardiovascular disease. CaMKII is uniquely capable of integrating various upstream signaling inputs, including redox signals, to regulate a wide range of downstream targets. The activation of CaMKII through the oxidation of a pair of oxidant-sensitive residues in its autoinhibitory region has been established as a significant driver of diseases. However, recent findings suggest that this oxidative activation mechanism is highly conserved and plays critical physiological roles. CaMKII oxidation, thus, is an example of evolutionary trade-offs that confer fitness benefits but also increase disease susceptibility. Understanding how CaMKII oxidation is regulated, and what downstream targets are regulated by oxidized CaMKII will help enhance the benefits while minimizing the detriments of this double-edged sword.
format Articulo
Articulo
author Wang, Qinchuan
author_facet Wang, Qinchuan
author_sort Wang, Qinchuan
title The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
title_short The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
title_full The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
title_fullStr The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
title_full_unstemmed The oxidative activation of Ca²⁺/calmodulin-dependent protein kinase II: a double-edged sword for health and disease
title_sort oxidative activation of ca²⁺/calmodulin-dependent protein kinase ii: a double-edged sword for health and disease
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/162884
work_keys_str_mv AT wangqinchuan theoxidativeactivationofca2calmodulindependentproteinkinaseiiadoubleedgedswordforhealthanddisease
AT wangqinchuan oxidativeactivationofca2calmodulindependentproteinkinaseiiadoubleedgedswordforhealthanddisease
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