Regulation of vascular remodeling by angiotensin-(1-9)

The renin angiotensin system (RAS) is involved in the regulation of vascular remodeling induced by hypertension, vascular injury and inflammation. Angiotensin II (Ang II) is the most important peptide of the classical RAS pathway. Ang II exerts its biological action by binding to AT1 (AT1R) and AT2...

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Detalles Bibliográficos
Autores principales: Chiong, Mario, Ramírez, Andrés, Sanhueza-Olivares, Fernanda, Gonzalez, Tamara, Martínez, Javiera, Norambuena-Soto Ignacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Bioquímica
ACE2
Ang-(1-9)
AT2R
vascular remodeling
VSMC
remodelado vascular
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/162883
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-162883
record_format dspace
spelling I19-R120-10915-1628832024-02-20T20:03:03Z http://sedici.unlp.edu.ar/handle/10915/162883 Regulation of vascular remodeling by angiotensin-(1-9) Chiong, Mario Ramírez, Andrés Sanhueza-Olivares, Fernanda Gonzalez, Tamara Martínez, Javiera Norambuena-Soto Ignacio 2022-10 2024-02-20T12:23:21Z en Bioquímica ACE2 Ang-(1-9) AT2R vascular remodeling VSMC remodelado vascular The renin angiotensin system (RAS) is involved in the regulation of vascular remodeling induced by hypertension, vascular injury and inflammation. Angiotensin II (Ang II) is the most important peptide of the classical RAS pathway. Ang II exerts its biological action by binding to AT1 (AT1R) and AT2 (AT2R) receptors. The discovery of the homologous angiotensin I converting enzyme (ACE2), unmasked an intricated system of RAS regulation. In the counter-regulatory RAS pathway, Ang-(1-7) binds and activates Mas receptor (MasR), while Ang-(1-9) binds and activates AT2R. This review is focused in the inhibitory effects on vascular remodeling of ACE2, Ang-(1-9) and AT2R. Because of these vascular effects, the manipulation of the counter regulatory RAS emerges as a suitable therapeutical alternative to treat vascular diseases. El sistema renina angiotensina (SRA) está involucrado en la regulación del remodelado vascular inducido por hipertensión, daño vascular e inflamación. La angiotensina II (Ang II) es el péptido más importante de la vía SRA clásica. Ang II ejerce su acción biológica al unirse a los receptores AT1 (RAT1) y AT2 (RAT2). El descubrimiento de la enzima convertidora de angiotensina I homóloga (ECA2), desenmascaró un intrincado sistema de regulación del SRA. En la vía SRA contrarreguladora, Ang-(1-7) se une y activa el receptor Mas (RMas), mientras que Ang-(1-9) se une y activa RAT2. Esta revisión se centra en los efectos inhibitorios sobre el remodelado vascular de ECA2, Ang-(1-9) y RAT2. Debido a estos efectos vasculares, la manipulación del SRA contrarregulador surge como una alternativa terapéutica adecuada para tratar enfermedades vasculares. Sociedad Argentina de Fisiología Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 50-60
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
ACE2
Ang-(1-9)
AT2R
vascular remodeling
VSMC
remodelado vascular
spellingShingle Bioquímica
ACE2
Ang-(1-9)
AT2R
vascular remodeling
VSMC
remodelado vascular
Chiong, Mario
Ramírez, Andrés
Sanhueza-Olivares, Fernanda
Gonzalez, Tamara
Martínez, Javiera
Norambuena-Soto Ignacio
Regulation of vascular remodeling by angiotensin-(1-9)
topic_facet Bioquímica
ACE2
Ang-(1-9)
AT2R
vascular remodeling
VSMC
remodelado vascular
description The renin angiotensin system (RAS) is involved in the regulation of vascular remodeling induced by hypertension, vascular injury and inflammation. Angiotensin II (Ang II) is the most important peptide of the classical RAS pathway. Ang II exerts its biological action by binding to AT1 (AT1R) and AT2 (AT2R) receptors. The discovery of the homologous angiotensin I converting enzyme (ACE2), unmasked an intricated system of RAS regulation. In the counter-regulatory RAS pathway, Ang-(1-7) binds and activates Mas receptor (MasR), while Ang-(1-9) binds and activates AT2R. This review is focused in the inhibitory effects on vascular remodeling of ACE2, Ang-(1-9) and AT2R. Because of these vascular effects, the manipulation of the counter regulatory RAS emerges as a suitable therapeutical alternative to treat vascular diseases.
format Articulo
Articulo
author Chiong, Mario
Ramírez, Andrés
Sanhueza-Olivares, Fernanda
Gonzalez, Tamara
Martínez, Javiera
Norambuena-Soto Ignacio
author_facet Chiong, Mario
Ramírez, Andrés
Sanhueza-Olivares, Fernanda
Gonzalez, Tamara
Martínez, Javiera
Norambuena-Soto Ignacio
author_sort Chiong, Mario
title Regulation of vascular remodeling by angiotensin-(1-9)
title_short Regulation of vascular remodeling by angiotensin-(1-9)
title_full Regulation of vascular remodeling by angiotensin-(1-9)
title_fullStr Regulation of vascular remodeling by angiotensin-(1-9)
title_full_unstemmed Regulation of vascular remodeling by angiotensin-(1-9)
title_sort regulation of vascular remodeling by angiotensin-(1-9)
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/162883
work_keys_str_mv AT chiongmario regulationofvascularremodelingbyangiotensin19
AT ramirezandres regulationofvascularremodelingbyangiotensin19
AT sanhuezaolivaresfernanda regulationofvascularremodelingbyangiotensin19
AT gonzaleztamara regulationofvascularremodelingbyangiotensin19
AT martinezjaviera regulationofvascularremodelingbyangiotensin19
AT norambuenasotoignacio regulationofvascularremodelingbyangiotensin19
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