Direct evidence for local IgE production in the human colonic mucosa

Understanding the biology of IgE in humans has become a matter of interest that remains incompletely understood due to the rarity of peripheral IgE+ cells. The increased incidence of allergic diseases and food-induced anaphylaxis overtime demands an urgent development of disease-modifying therapies...

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Autores principales: Canziani, Karina Eva, Pucci Molineris, Melisa Eliana, Guzman, Luciana, Bermedo, Viviana, García, Marcela Nilda, Altamirano, Eugenia Margarita, Muglia, Cecilia Isabel, Docena, Guillermo Horacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
allergic sensitization
food allergens
germinal center
IgE synthesis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/162851
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-162851
record_format dspace
spelling I19-R120-10915-1628512024-02-19T20:08:20Z http://sedici.unlp.edu.ar/handle/10915/162851 Direct evidence for local IgE production in the human colonic mucosa Canziani, Karina Eva Pucci Molineris, Melisa Eliana Guzman, Luciana Bermedo, Viviana García, Marcela Nilda Altamirano, Eugenia Margarita Muglia, Cecilia Isabel Docena, Guillermo Horacio 2021-05-02 2024-02-19T16:29:32Z en Ciencias Médicas allergic sensitization food allergens germinal center IgE synthesis Understanding the biology of IgE in humans has become a matter of interest that remains incompletely understood due to the rarity of peripheral IgE+ cells. The increased incidence of allergic diseases and food-induced anaphylaxis overtime demands an urgent development of disease-modifying therapies that reverse the synthesis of IgE and the induction of IgE-mediated allergic reactions. Although some reports showed specific IgE in stools and IgE+ cells in the gastrointestinal tract of allergic patients, the microanatomical location of the class-switch recombination (CSR) to ε chain is largely unknown. This isotype is produced through CSR mechanism by activated IgM-producing B cells (direct switch) or following IgG+ B memory cell-switch to ε chain (sequential switch) in a Th2 milieu with the induction of the cytidine deaminase (AID). It has been demonstrated that this mechanism occurs prior to germinal center (GC) formation in secondary lymphoid tissues such as lymph nodes and tonsils, but it is controversial whether the IgE isotype switching can occur in the human intestinal mucosa and which niches could be involved. Our study aimed to investigate the local IgE synthesis in the stroma of juvenile colonic polyps (JP) from patients with rectal bleeding and the relationship between IgE production and food sensitization, a risk factor for food allergy. Instituto de Estudios Inmunológicos y Fisiopatológicos Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 1545-1549
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
allergic sensitization
food allergens
germinal center
IgE synthesis
spellingShingle Ciencias Médicas
allergic sensitization
food allergens
germinal center
IgE synthesis
Canziani, Karina Eva
Pucci Molineris, Melisa Eliana
Guzman, Luciana
Bermedo, Viviana
García, Marcela Nilda
Altamirano, Eugenia Margarita
Muglia, Cecilia Isabel
Docena, Guillermo Horacio
Direct evidence for local IgE production in the human colonic mucosa
topic_facet Ciencias Médicas
allergic sensitization
food allergens
germinal center
IgE synthesis
description Understanding the biology of IgE in humans has become a matter of interest that remains incompletely understood due to the rarity of peripheral IgE+ cells. The increased incidence of allergic diseases and food-induced anaphylaxis overtime demands an urgent development of disease-modifying therapies that reverse the synthesis of IgE and the induction of IgE-mediated allergic reactions. Although some reports showed specific IgE in stools and IgE+ cells in the gastrointestinal tract of allergic patients, the microanatomical location of the class-switch recombination (CSR) to ε chain is largely unknown. This isotype is produced through CSR mechanism by activated IgM-producing B cells (direct switch) or following IgG+ B memory cell-switch to ε chain (sequential switch) in a Th2 milieu with the induction of the cytidine deaminase (AID). It has been demonstrated that this mechanism occurs prior to germinal center (GC) formation in secondary lymphoid tissues such as lymph nodes and tonsils, but it is controversial whether the IgE isotype switching can occur in the human intestinal mucosa and which niches could be involved. Our study aimed to investigate the local IgE synthesis in the stroma of juvenile colonic polyps (JP) from patients with rectal bleeding and the relationship between IgE production and food sensitization, a risk factor for food allergy.
format Articulo
Articulo
author Canziani, Karina Eva
Pucci Molineris, Melisa Eliana
Guzman, Luciana
Bermedo, Viviana
García, Marcela Nilda
Altamirano, Eugenia Margarita
Muglia, Cecilia Isabel
Docena, Guillermo Horacio
author_facet Canziani, Karina Eva
Pucci Molineris, Melisa Eliana
Guzman, Luciana
Bermedo, Viviana
García, Marcela Nilda
Altamirano, Eugenia Margarita
Muglia, Cecilia Isabel
Docena, Guillermo Horacio
author_sort Canziani, Karina Eva
title Direct evidence for local IgE production in the human colonic mucosa
title_short Direct evidence for local IgE production in the human colonic mucosa
title_full Direct evidence for local IgE production in the human colonic mucosa
title_fullStr Direct evidence for local IgE production in the human colonic mucosa
title_full_unstemmed Direct evidence for local IgE production in the human colonic mucosa
title_sort direct evidence for local ige production in the human colonic mucosa
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/162851
work_keys_str_mv AT canzianikarinaeva directevidenceforlocaligeproductioninthehumancolonicmucosa
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