Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
Background: In January 2005, Rasulov et al. originally published “First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns”. Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) i...
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2015
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/162142 |
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I19-R120-10915-162142 |
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I19-R120-10915-1621422023-12-30T04:06:35Z http://sedici.unlp.edu.ar/handle/10915/162142 Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns Mansilla, Eduardo Marín, Gustavo Horacio Berges, Mirta Scafatti, Silvia Rivas, Jaime Núñez, Andrea Menvielle, Martin Lamonega, Roberto Gardiner, Cecilia Drago, Hugo Sturla, Flavio Portas, Mercedes Bossi, Silvia Castuma, María Victoria Peña Luengas, Sandra Roque, Gustavo Martire, Karina Tau, Jose María Orlandi, Gabriel Tarditti, Adrián 2015 2023-12-29T17:33:18Z en Ciencias Médicas Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells Background: In January 2005, Rasulov et al. originally published “First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns”. Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine. Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns while working with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry of Health, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after early escharotomy. Results: So far, our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of CMSCs. Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the world. CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation. Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells |
| spellingShingle |
Ciencias Médicas Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells Mansilla, Eduardo Marín, Gustavo Horacio Berges, Mirta Scafatti, Silvia Rivas, Jaime Núñez, Andrea Menvielle, Martin Lamonega, Roberto Gardiner, Cecilia Drago, Hugo Sturla, Flavio Portas, Mercedes Bossi, Silvia Castuma, María Victoria Peña Luengas, Sandra Roque, Gustavo Martire, Karina Tau, Jose María Orlandi, Gabriel Tarditti, Adrián Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| topic_facet |
Ciencias Médicas Burns Cadaveric Transplantation Skin regeneration Mesenchymal stem cells |
| description |
Background: In January 2005, Rasulov et al. originally published “First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns”. Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.
Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns while working with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry of Health, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after early escharotomy.
Results: So far, our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of CMSCs.
Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the world.
CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation. |
| format |
Articulo Articulo |
| author |
Mansilla, Eduardo Marín, Gustavo Horacio Berges, Mirta Scafatti, Silvia Rivas, Jaime Núñez, Andrea Menvielle, Martin Lamonega, Roberto Gardiner, Cecilia Drago, Hugo Sturla, Flavio Portas, Mercedes Bossi, Silvia Castuma, María Victoria Peña Luengas, Sandra Roque, Gustavo Martire, Karina Tau, Jose María Orlandi, Gabriel Tarditti, Adrián |
| author_facet |
Mansilla, Eduardo Marín, Gustavo Horacio Berges, Mirta Scafatti, Silvia Rivas, Jaime Núñez, Andrea Menvielle, Martin Lamonega, Roberto Gardiner, Cecilia Drago, Hugo Sturla, Flavio Portas, Mercedes Bossi, Silvia Castuma, María Victoria Peña Luengas, Sandra Roque, Gustavo Martire, Karina Tau, Jose María Orlandi, Gabriel Tarditti, Adrián |
| author_sort |
Mansilla, Eduardo |
| title |
Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| title_short |
Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| title_full |
Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| title_fullStr |
Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| title_full_unstemmed |
Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| title_sort |
cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns |
| publishDate |
2015 |
| url |
http://sedici.unlp.edu.ar/handle/10915/162142 |
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