Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet

Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the eff...

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Autores principales: Degrave, V., Battisti, M., Vega Joubert, M., Ingaramo, P., Vaccarini, Cristian Adrián, Sedan, Daniela Yazmine, Andrinolo, Darío, D’Alessandro, M., Oliva, M.E.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/160491
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-160491
record_format dspace
spelling I19-R120-10915-1604912023-11-23T20:43:23Z http://sedici.unlp.edu.ar/handle/10915/160491 Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet Degrave, V. Battisti, M. Vega Joubert, M. Ingaramo, P. Vaccarini, Cristian Adrián Sedan, Daniela Yazmine Andrinolo, Darío D’Alessandro, M. Oliva, M.E. 2023 2023-11-23T18:29:23Z en Química Biología cannabis oil female rats Metabolic Syndrome liver cannabinoid-induced tetrad blood pressure metabolic parameters Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD. Centro de Investigación y Desarrollo en Criotecnología de Alimentos Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
spellingShingle Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
Degrave, V.
Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
topic_facet Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
description Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD.
format Articulo
Articulo
author Degrave, V.
Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
author_facet Degrave, V.
Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
author_sort Degrave, V.
title Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_short Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_fullStr Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full_unstemmed Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_sort cannabis oil: effects on cannabinoid-induced tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/160491
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