Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves

Schinus lentiscifolius (Anacardiaceae) is widely used in folk medicine for treating gastrointestinal and emotional complaints but there are no scientific studies that support these uses. This work aims at evaluating the antispasmodic and central effects of S. lentiscifolius as well as the flavonoids...

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Detalles Bibliográficos
Autores principales: Vanegas Andrade, Catalina, Matera, Soledad Inés, Bayley Agnoli, Matías, Colareda, Germán Andrés, Ruiz, María Esperanza, Prieto, Julián José, Retta, Daiana, Van Baren, Catalina, Consolini, Alicia Elvira, Ragone, María Inés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Biología
Schinus lentiscifolius
Essential oil
Smooth muscle
Antidepressant
Anxiolytic
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/160417
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-160417
record_format dspace
spelling I19-R120-10915-1604172023-11-22T20:07:44Z http://sedici.unlp.edu.ar/handle/10915/160417 Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves Vanegas Andrade, Catalina Matera, Soledad Inés Bayley Agnoli, Matías Colareda, Germán Andrés Ruiz, María Esperanza Prieto, Julián José Retta, Daiana Van Baren, Catalina Consolini, Alicia Elvira Ragone, María Inés 2022 2023-11-22T17:00:33Z en Biología Schinus lentiscifolius Essential oil Smooth muscle Antidepressant Anxiolytic Schinus lentiscifolius (Anacardiaceae) is widely used in folk medicine for treating gastrointestinal and emotional complaints but there are no scientific studies that support these uses. This work aims at evaluating the antispasmodic and central effects of S. lentiscifolius as well as the flavonoids presence in the tincture (SchT) and the composition of the essential oil (SchO). SchT inhibited the concentrationresponse curves (CRC) of carbachol and calcium in a non-competitive way in isolated rat intestine, bladder and uterus. SchT also non-competitively inhibited the CRC of histamine in guinea-pig intestine and the CRCs of serotonin and oxytocin in rat uterus. Isoquercetin and rutin were identified in SchT. The behavioral effects of SchT, SchO and infusion of S. lentiscifolius leaves (SchW) were tested in mice. These extracts showed an anxiolytic-like effect in the novelty-suppressed feeding test, which was reversed by flumazenil except in SchO-treated mice. Only SchO reduced the spontaneous locomotor function in the open field test. Also, SchT and SchW decreased immobility time in both, the tail suspension (TST) and forced swimming tests, while SchO produced the same effect in the TST. D-limonene and a-santalol were the main components found in SchO. The results demonstrated that extracts obtained from S. lentiscifolius leaves were effective as intestinal, urinary and uterine antispasmodics. SchT and SchW exhibited anxiolytic and antidepressant properties without sedation, whereas SchO showed also sedative properties. Therefore, the present study gives preclinical support to the traditional use of this plant for gastrointestinal and depressive or emotional symptoms. Facultad de Ciencias Exactas Articulo Articulo http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) application/pdf 141-151
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Schinus lentiscifolius
Essential oil
Smooth muscle
Antidepressant
Anxiolytic
spellingShingle Biología
Schinus lentiscifolius
Essential oil
Smooth muscle
Antidepressant
Anxiolytic
Vanegas Andrade, Catalina
Matera, Soledad Inés
Bayley Agnoli, Matías
Colareda, Germán Andrés
Ruiz, María Esperanza
Prieto, Julián José
Retta, Daiana
Van Baren, Catalina
Consolini, Alicia Elvira
Ragone, María Inés
Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
topic_facet Biología
Schinus lentiscifolius
Essential oil
Smooth muscle
Antidepressant
Anxiolytic
description Schinus lentiscifolius (Anacardiaceae) is widely used in folk medicine for treating gastrointestinal and emotional complaints but there are no scientific studies that support these uses. This work aims at evaluating the antispasmodic and central effects of S. lentiscifolius as well as the flavonoids presence in the tincture (SchT) and the composition of the essential oil (SchO). SchT inhibited the concentrationresponse curves (CRC) of carbachol and calcium in a non-competitive way in isolated rat intestine, bladder and uterus. SchT also non-competitively inhibited the CRC of histamine in guinea-pig intestine and the CRCs of serotonin and oxytocin in rat uterus. Isoquercetin and rutin were identified in SchT. The behavioral effects of SchT, SchO and infusion of S. lentiscifolius leaves (SchW) were tested in mice. These extracts showed an anxiolytic-like effect in the novelty-suppressed feeding test, which was reversed by flumazenil except in SchO-treated mice. Only SchO reduced the spontaneous locomotor function in the open field test. Also, SchT and SchW decreased immobility time in both, the tail suspension (TST) and forced swimming tests, while SchO produced the same effect in the TST. D-limonene and a-santalol were the main components found in SchO. The results demonstrated that extracts obtained from S. lentiscifolius leaves were effective as intestinal, urinary and uterine antispasmodics. SchT and SchW exhibited anxiolytic and antidepressant properties without sedation, whereas SchO showed also sedative properties. Therefore, the present study gives preclinical support to the traditional use of this plant for gastrointestinal and depressive or emotional symptoms.
format Articulo
Articulo
author Vanegas Andrade, Catalina
Matera, Soledad Inés
Bayley Agnoli, Matías
Colareda, Germán Andrés
Ruiz, María Esperanza
Prieto, Julián José
Retta, Daiana
Van Baren, Catalina
Consolini, Alicia Elvira
Ragone, María Inés
author_facet Vanegas Andrade, Catalina
Matera, Soledad Inés
Bayley Agnoli, Matías
Colareda, Germán Andrés
Ruiz, María Esperanza
Prieto, Julián José
Retta, Daiana
Van Baren, Catalina
Consolini, Alicia Elvira
Ragone, María Inés
author_sort Vanegas Andrade, Catalina
title Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
title_short Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
title_full Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
title_fullStr Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
title_full_unstemmed Antispasmodic, antidepressant and anxiolytic effects of extracts from Schinus lentiscifolius Marchand leaves
title_sort antispasmodic, antidepressant and anxiolytic effects of extracts from schinus lentiscifolius marchand leaves
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/160417
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