Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed th...

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Autores principales:	Garofalo, Federico Mariano, Sbaraglini, María Laura, Barrionuevo, Emilia Mercedes, Peralta, Estefanía, Bonifazi, Evelyn L., Talevi, Alan, Gavernet, Luciana
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2023
Materias:	Biología anti-inflammatory drugs anticonvulsant drugs codrugs epilepsy hybrid drugs multitarget drugs nipecotic acid parabens valproic acid
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/160072
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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spelling	I19-R120-10915-1600722024-03-11T16:19:37Z http://sedici.unlp.edu.ar/handle/10915/160072 Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid Garofalo, Federico Mariano Sbaraglini, María Laura Barrionuevo, Emilia Mercedes Peralta, Estefanía Bonifazi, Evelyn L. Talevi, Alan Gavernet, Luciana 2023-05-25 2023-11-13T14:03:25Z en Biología anti-inflammatory drugs anticonvulsant drugs codrugs epilepsy hybrid drugs multitarget drugs nipecotic acid parabens valproic acid This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes. Facultad de Ciencias Exactas Universidad de Buenos Aires Laboratorio de Investigación y Desarrollo de Bioactivos Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología anti-inflammatory drugs anticonvulsant drugs codrugs epilepsy hybrid drugs multitarget drugs nipecotic acid parabens valproic acid
spellingShingle	Biología anti-inflammatory drugs anticonvulsant drugs codrugs epilepsy hybrid drugs multitarget drugs nipecotic acid parabens valproic acid Garofalo, Federico Mariano Sbaraglini, María Laura Barrionuevo, Emilia Mercedes Peralta, Estefanía Bonifazi, Evelyn L. Talevi, Alan Gavernet, Luciana Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
topic_facet	Biología anti-inflammatory drugs anticonvulsant drugs codrugs epilepsy hybrid drugs multitarget drugs nipecotic acid parabens valproic acid
description	This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes.
format	Articulo Articulo
author	Garofalo, Federico Mariano Sbaraglini, María Laura Barrionuevo, Emilia Mercedes Peralta, Estefanía Bonifazi, Evelyn L. Talevi, Alan Gavernet, Luciana
author_facet	Garofalo, Federico Mariano Sbaraglini, María Laura Barrionuevo, Emilia Mercedes Peralta, Estefanía Bonifazi, Evelyn L. Talevi, Alan Gavernet, Luciana
author_sort	Garofalo, Federico Mariano
title	Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_short	Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_full	Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_fullStr	Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_full_unstemmed	Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_sort	synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
publishDate	2023
url	http://sedici.unlp.edu.ar/handle/10915/160072
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Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

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