Protein repeats evolve and emerge in giant viruses

Nucleocytoplasmatic large DNA viruses (NCLDVs or giant viruses) stand out because of their relatively large genomes encoding hundreds of proteins. These species give us an unprecedented opportunity to study the emergence and evolution of repeats in protein sequences. On the one hand, as viruses, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Erdozain Bagolin, Sofía Agostina, Barrionuevo, Emilia Mercedes, Ripoll, Lucas, Mier, Pablo, Andrade Navarro, Miguel A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Biología
Virus
Tandem Repeats
Evolución
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/159894
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-159894
record_format dspace
spelling I19-R120-10915-1598942023-11-07T20:07:10Z http://sedici.unlp.edu.ar/handle/10915/159894 Protein repeats evolve and emerge in giant viruses Erdozain Bagolin, Sofía Agostina Barrionuevo, Emilia Mercedes Ripoll, Lucas Mier, Pablo Andrade Navarro, Miguel A. 2023-04-07 2023-11-07T17:33:20Z en Biología Virus Tandem Repeats Evolución Nucleocytoplasmatic large DNA viruses (NCLDVs or giant viruses) stand out because of their relatively large genomes encoding hundreds of proteins. These species give us an unprecedented opportunity to study the emergence and evolution of repeats in protein sequences. On the one hand, as viruses, these species have a restricted set of functions, which can help us better define the functional landscape of repeats. On the other hand, given the particular use of the genetic machinery of the host, it is worth asking whether this allows the variations of genetic material that lead to repeats in non-viral species. To support research in the characterization of repeat protein evolution and function, we present here an analysis focused on the repeat proteins of giant viruses, namely tandem repeats (TRs), short repeats (SRs), and homorepeats (polyX). Proteins with large and short repeats are not very frequent in non-eukaryotic organisms because of the difficulties that their folding may entail; however, their presence in giant viruses remarks their advantage for performance in the protein environment of the eukaryotic host. The heterogeneous content of these TRs, SRs and polyX in some viruses hints at diverse needs. Comparisons to homologs suggest that the mechanisms that generate these repeats are extensively used by some of these viruses, but also their capacity to adopt genes with repeats. Giant viruses could be very good models for the study of the emergence and evolution of protein repeats. Instituto de Biotecnología y Biología Molecular Facultad de Ciencias Exactas Universidad Nacional de Quilmes Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Virus
Tandem Repeats
Evolución
spellingShingle Biología
Virus
Tandem Repeats
Evolución
Erdozain Bagolin, Sofía Agostina
Barrionuevo, Emilia Mercedes
Ripoll, Lucas
Mier, Pablo
Andrade Navarro, Miguel A.
Protein repeats evolve and emerge in giant viruses
topic_facet Biología
Virus
Tandem Repeats
Evolución
description Nucleocytoplasmatic large DNA viruses (NCLDVs or giant viruses) stand out because of their relatively large genomes encoding hundreds of proteins. These species give us an unprecedented opportunity to study the emergence and evolution of repeats in protein sequences. On the one hand, as viruses, these species have a restricted set of functions, which can help us better define the functional landscape of repeats. On the other hand, given the particular use of the genetic machinery of the host, it is worth asking whether this allows the variations of genetic material that lead to repeats in non-viral species. To support research in the characterization of repeat protein evolution and function, we present here an analysis focused on the repeat proteins of giant viruses, namely tandem repeats (TRs), short repeats (SRs), and homorepeats (polyX). Proteins with large and short repeats are not very frequent in non-eukaryotic organisms because of the difficulties that their folding may entail; however, their presence in giant viruses remarks their advantage for performance in the protein environment of the eukaryotic host. The heterogeneous content of these TRs, SRs and polyX in some viruses hints at diverse needs. Comparisons to homologs suggest that the mechanisms that generate these repeats are extensively used by some of these viruses, but also their capacity to adopt genes with repeats. Giant viruses could be very good models for the study of the emergence and evolution of protein repeats.
format Articulo
Articulo
author Erdozain Bagolin, Sofía Agostina
Barrionuevo, Emilia Mercedes
Ripoll, Lucas
Mier, Pablo
Andrade Navarro, Miguel A.
author_facet Erdozain Bagolin, Sofía Agostina
Barrionuevo, Emilia Mercedes
Ripoll, Lucas
Mier, Pablo
Andrade Navarro, Miguel A.
author_sort Erdozain Bagolin, Sofía Agostina
title Protein repeats evolve and emerge in giant viruses
title_short Protein repeats evolve and emerge in giant viruses
title_full Protein repeats evolve and emerge in giant viruses
title_fullStr Protein repeats evolve and emerge in giant viruses
title_full_unstemmed Protein repeats evolve and emerge in giant viruses
title_sort protein repeats evolve and emerge in giant viruses
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/159894
work_keys_str_mv AT erdozainbagolinsofiaagostina proteinrepeatsevolveandemergeingiantviruses
AT barrionuevoemiliamercedes proteinrepeatsevolveandemergeingiantviruses
AT ripolllucas proteinrepeatsevolveandemergeingiantviruses
AT mierpablo proteinrepeatsevolveandemergeingiantviruses
AT andradenavarromiguela proteinrepeatsevolveandemergeingiantviruses
_version_ 1807221775688269824

Ejemplares similares