Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina

Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. ,ese data should be known, in order to perform local policies towards AMR reduction. This work aim...

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Autores principales: Boni, Silvia, Marín, Gustavo Horacio, Campaña, Laura, Marín, Lupe, Risso Patrón, Soledad, Marin, Gina, Gabriel, Fernanda, Corso, Alejandra, Garay, Valeria, Limeres, Manuel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Medicina
Carbapenem
antibiotics
consumption
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/159640
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-159640
record_format dspace
spelling I19-R120-10915-1596402023-10-31T20:08:22Z http://sedici.unlp.edu.ar/handle/10915/159640 Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina Boni, Silvia Marín, Gustavo Horacio Campaña, Laura Marín, Lupe Risso Patrón, Soledad Marin, Gina Gabriel, Fernanda Corso, Alejandra Garay, Valeria Limeres, Manuel 2022-02-02 2023-10-31T17:47:27Z en Medicina Carbapenem antibiotics consumption Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. ,ese data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/ resistance ratio “R” was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C : R = 0.58; p = 0.003 and F : R = 0.77; p = 0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs. Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Carbapenem
antibiotics
consumption
spellingShingle Medicina
Carbapenem
antibiotics
consumption
Boni, Silvia
Marín, Gustavo Horacio
Campaña, Laura
Marín, Lupe
Risso Patrón, Soledad
Marin, Gina
Gabriel, Fernanda
Corso, Alejandra
Garay, Valeria
Limeres, Manuel
Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
topic_facet Medicina
Carbapenem
antibiotics
consumption
description Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. ,ese data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/ resistance ratio “R” was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C : R = 0.58; p = 0.003 and F : R = 0.77; p = 0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs.
format Articulo
Articulo
author Boni, Silvia
Marín, Gustavo Horacio
Campaña, Laura
Marín, Lupe
Risso Patrón, Soledad
Marin, Gina
Gabriel, Fernanda
Corso, Alejandra
Garay, Valeria
Limeres, Manuel
author_facet Boni, Silvia
Marín, Gustavo Horacio
Campaña, Laura
Marín, Lupe
Risso Patrón, Soledad
Marin, Gina
Gabriel, Fernanda
Corso, Alejandra
Garay, Valeria
Limeres, Manuel
author_sort Boni, Silvia
title Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
title_short Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
title_full Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
title_fullStr Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
title_full_unstemmed Association between Consumption of Fluoroquinolones and Carbapenems and Their Resistance Rates in Pseudomonas aeruginosa in Argentina
title_sort association between consumption of fluoroquinolones and carbapenems and their resistance rates in pseudomonas aeruginosa in argentina
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/159640
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