Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina

Objective: To assess the efficacy of antibiotic usage for the treatment of puerperal metritis (PM) and its association with reproductive performance, a retrospective cohort study including a total of 9168 records of cows from a dairy farm in Argentina was run. Material and methods: Cows having a PM...

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Autores principales: Sota, Rodolfo Luzbel de la, Corva, Santiago Gerardo, Domínguez, Germán, Madoz, Laura Vanina, Jaureguiberry, María, Giuliodori, Mauricio Javier
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Veterinarias
Uterus
dairy cow
ceftiofur
treatment efficacy
antimicrobial resistance
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/159499
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-159499
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Uterus
dairy cow
ceftiofur
treatment efficacy
antimicrobial resistance
spellingShingle Ciencias Veterinarias
Uterus
dairy cow
ceftiofur
treatment efficacy
antimicrobial resistance
Sota, Rodolfo Luzbel de la
Corva, Santiago Gerardo
Domínguez, Germán
Madoz, Laura Vanina
Jaureguiberry, María
Giuliodori, Mauricio Javier
Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
topic_facet Ciencias Veterinarias
Uterus
dairy cow
ceftiofur
treatment efficacy
antimicrobial resistance
description Objective: To assess the efficacy of antibiotic usage for the treatment of puerperal metritis (PM) and its association with reproductive performance, a retrospective cohort study including a total of 9168 records of cows from a dairy farm in Argentina was run. Material and methods: Cows having a PM3 (metricheck, scale 0–3) and treated with ceftiofur (ceftiofur crystalline free acid, 6.6 mg/kg) at 0–21 days postpartum (p. p.) (n = 2688), and cows having a PM 1–2 and not treated with an antibiotic at 0–21 days p. p. (n = 6480) were included in the study. All cows were reexamined with metricheck to assess the clinical cure (vaginal discharge [VD] score 0), partial cure (VD score similar or lower than previous), no cure (VD score higher than previous). Cows with a metricheck VD1–3 after 0–21 days p. p. were diagnosed as clinical endometritis (CE) 1–3. The occurrence of PM1–3, cure rate, calving to conception interval, the hazard of pregnancy, odds for non-pregnancy, and odds for CE were analyzed using SAS software. Results: A total of 8876 PM1–3 records were included, 2435 records of PM3 treatments with ceftiofur (27.43 %), and 6441 records of PM1–2 (72.57 %) with no treatment. Cows having PM1 and PM2 became pregnant 14 and 12 days earlier than cows with PM3 (p < 0.001). The PM3 ceftiofur treated cows had a clinical cure of 24.85 % (PM0); 53.63 % had a partially cure; and 18.52 % no cure. Conversely, cows with PM1–2 had a 51.96 %, 20.70 %, and 24.53 % cure rate, respectively (p < 0.001). Cows having complete cure became pregnant 13 and 11 days earlier than cows having partial cure and no cure (p < 0.001). Cows that had PM3 during the first 21 days p. p. had twice the chances of developing CE compared to cows having PM1–2 (41.28 % vs. 24.14 %, p < 0.001). After 21 days p. p., less than 1 % of cows with clinical cure developed CE compared to 63.32 % that developed CE with partial cure, and 38.21 % with no cure (p < 0.001). Conclusion and clinical relevance: After ceftiofur treatment, 78 % of cows were cured when measured by disappearance of fetid VD but only 25 % of cows had clinical cure when measured by appearance of a clear VD. The cows that remained with clinical metritis had more chances of having CE after 21 days p. p. and had more days open than cows with clear normal VD.
format Articulo
Articulo
author Sota, Rodolfo Luzbel de la
Corva, Santiago Gerardo
Domínguez, Germán
Madoz, Laura Vanina
Jaureguiberry, María
Giuliodori, Mauricio Javier
author_facet Sota, Rodolfo Luzbel de la
Corva, Santiago Gerardo
Domínguez, Germán
Madoz, Laura Vanina
Jaureguiberry, María
Giuliodori, Mauricio Javier
author_sort Sota, Rodolfo Luzbel de la
title Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
title_short Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
title_full Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
title_fullStr Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
title_full_unstemmed Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina
title_sort analysis of puerperal metritis treatment records in a grazing dairy farm in argentina
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/159499
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spelling I19-R120-10915-1594992023-10-28T04:07:10Z http://sedici.unlp.edu.ar/handle/10915/159499 Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina Analyse der Aufzeichnungen zur Behandlung puerperaler Metritiden von Kühen in einem Milchviehbetrieb mit Weidehaltung in Argentinien Sota, Rodolfo Luzbel de la Corva, Santiago Gerardo Domínguez, Germán Madoz, Laura Vanina Jaureguiberry, María Giuliodori, Mauricio Javier 2020-08-21 2023-10-27T16:57:48Z en Ciencias Veterinarias Uterus dairy cow ceftiofur treatment efficacy antimicrobial resistance Objective: To assess the efficacy of antibiotic usage for the treatment of puerperal metritis (PM) and its association with reproductive performance, a retrospective cohort study including a total of 9168 records of cows from a dairy farm in Argentina was run. Material and methods: Cows having a PM3 (metricheck, scale 0–3) and treated with ceftiofur (ceftiofur crystalline free acid, 6.6 mg/kg) at 0–21 days postpartum (p. p.) (n = 2688), and cows having a PM 1–2 and not treated with an antibiotic at 0–21 days p. p. (n = 6480) were included in the study. All cows were reexamined with metricheck to assess the clinical cure (vaginal discharge [VD] score 0), partial cure (VD score similar or lower than previous), no cure (VD score higher than previous). Cows with a metricheck VD1–3 after 0–21 days p. p. were diagnosed as clinical endometritis (CE) 1–3. The occurrence of PM1–3, cure rate, calving to conception interval, the hazard of pregnancy, odds for non-pregnancy, and odds for CE were analyzed using SAS software. Results: A total of 8876 PM1–3 records were included, 2435 records of PM3 treatments with ceftiofur (27.43 %), and 6441 records of PM1–2 (72.57 %) with no treatment. Cows having PM1 and PM2 became pregnant 14 and 12 days earlier than cows with PM3 (p < 0.001). The PM3 ceftiofur treated cows had a clinical cure of 24.85 % (PM0); 53.63 % had a partially cure; and 18.52 % no cure. Conversely, cows with PM1–2 had a 51.96 %, 20.70 %, and 24.53 % cure rate, respectively (p < 0.001). Cows having complete cure became pregnant 13 and 11 days earlier than cows having partial cure and no cure (p < 0.001). Cows that had PM3 during the first 21 days p. p. had twice the chances of developing CE compared to cows having PM1–2 (41.28 % vs. 24.14 %, p < 0.001). After 21 days p. p., less than 1 % of cows with clinical cure developed CE compared to 63.32 % that developed CE with partial cure, and 38.21 % with no cure (p < 0.001). Conclusion and clinical relevance: After ceftiofur treatment, 78 % of cows were cured when measured by disappearance of fetid VD but only 25 % of cows had clinical cure when measured by appearance of a clear VD. The cows that remained with clinical metritis had more chances of having CE after 21 days p. p. and had more days open than cows with clear normal VD. Ziel: Bewertung der Wirksamkeit von Antibiotika zur Behandlung der puerperalen Metritis (PM) und ihres Effekt auf die Reproduktionsleistung von Milchkühen. Material und Methoden: Die retrospektive Kohortenstudie wertete 9168Datensätzen von Kühen eines Milchviehbetriebs mit ganzjähriger Weidehaltung in Argentinien aus. Es handelte sich um Kühe mit einer PM 3.Grades (PM3, diagnostiziert mittels Metricheck, Skala 0–3), die 0–21 Tage post partum (p. p.) mit Ceftiofur (freie kristalline Säure, 6,6mg/kg) behandelt worden waren (n = 2688), sowie unbehandelte Kühe mit einer PM 1. und 2.Grades (PM1–2; n = 6480). Alle Kühe wurden 21 Tage p. p. erneut mittels Metricheck untersucht, um die klinische Heilung (Vaginalausfluss [VD], Score 0), eine teilweise Heilung (VD-Score gleich oder niedriger als zuvor) oder keine Heilung (VD-Score höher als zuvor) festzustellen. Bei Kühen mit VD1–3 wurde die Diagnose klinische Endometritis (KE) 1–3 gestellt. Das Auftreten von PM1–3, die Heilungsrate, die Güstzeit, das Risiko einer Trächtigkeit, einer nicht eintretenden Trächtigkeit sowie einer KE wurden mittels SAS-Software analysiert. Ergebnisse: Die finale Auswertung berücksichtigte 8876Datensätze (PM3: n = 2435, 27,43%; PM1–2: n = 6441, 72,57%). Kühe mit PM1 und PM2 wurden 14 bzw. 12Tage früher trächtig als Kühe mit PM3 (p < 0,001). Die mit Ceftiofur behandelten PM3-Kühe wiesen zu 24,85 % eine klinische Heilung auf, zu 53,63% eine teilweise Heilung und zu 18,52% keine Heilung. Dagegen ergab sich bei Kühen mit PM1–2 eine Heilungsrate von 51,96%, eine teilweise Heilung bei 20,70% und keine Heilung bei 24,53% (p<0,001). Vollständig geheilte Kühe wurden 13 bzw. 11Tage früher trächtig als teilweise oder nicht geheilte Kühe (p < 0,001). Bei Kühen mit PM3 in den ersten 21 Tagen p.p. war im Vergleich zu Kühen mit PM1–2 die Wahrscheinlichkeit, später eine KE zu entwickeln, doppelt so groß (41,28 % vs. 24,14%, p < 0,001). Weniger als 1% der Kühe mit klinischer Heilung wiesen später eine KE auf. Bei Tieren mit teilweiser oder ohne Heilung betrug dieser Anteil 63,32% bzw. 38,21% (p < 0,001). Schlussfolgerung und klinische Relevanz: Nach der Ceftiofur-Behandlung galten 78 % der PM3-Kühe als geheilt, wenn die Heilung als fehlender übelriechender VD beurteilt wurde. Als vollständig geheilt (klarer Ausfluss) wurden jedoch nur 25% der Kühe bewertet. Kühe mit diagnostizierter Metritis bei der Nachuntersuchung hatten nach mehr als 21 Tagen p. p. ein höheres Risiko einer KE und längere Güstzeiten als Kühe mit physiologischem klarem VD. Facultad de Ciencias Veterinarias Consejo Nacional de Investigaciones Científicas y Técnicas Articulo Articulo http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) application/pdf 239-248

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