Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows

Cows transitioning from late gestation to early lactation experience an increase in energy demands, which lead to a negative energy balance (NEB) because the greater energy requirement is not fully synchronized with the intake of dry matter. In this context, there is an increase in plasma NEFA and g...

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Autores principales: Miqueo, E., Chiarle, Ayelén, Giuliodori, Mauricio Javier, Relling, Alejandro Enrique
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Veterinarias
Prepartum NEFA
Prepartum ghrelin
Prepartum GIP
Resumption to ovarian activity
Dairy cow
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/159496
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-159496
record_format dspace
spelling I19-R120-10915-1594962023-10-28T04:07:11Z http://sedici.unlp.edu.ar/handle/10915/159496 Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows Miqueo, E. Chiarle, Ayelén Giuliodori, Mauricio Javier Relling, Alejandro Enrique 2019-04-26 2023-10-27T16:35:21Z en Ciencias Veterinarias Prepartum NEFA Prepartum ghrelin Prepartum GIP Resumption to ovarian activity Dairy cow Cows transitioning from late gestation to early lactation experience an increase in energy demands, which lead to a negative energy balance (NEB) because the greater energy requirement is not fully synchronized with the intake of dry matter. In this context, there is an increase in plasma NEFA and ghrelin concentrations and a decrease in plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) concentrations. This situation could have a negative impact on the return to cyclicity because some of these variables have been associated with reduced GnRH and LH pulsatility (high NEFA and low insulin concentrations). However, there are no studies showing the relationship between ghrelin or GIP and reproductive performance. It is known that these hormones are related with lipolysis and NEB, with NEB being one of the main determinants of GnRH pulse generator activity. Thus, the objective of the present study was to evaluate the association between plasma NEFA concentration and metabolic hormones (insulin, ghrelin, and GIP) before parturition and their associations with the resumption of postpartum ovulations in dairy cows. A completely randomized block design was used in a commercial dairy herd with sampling day (visit to farm) as the blocking criteria. Holstein cows (n = 92) were screened for plasma NEFA concentration -5 d (+/-2 d) relative to the expected parturition day, and top and bottom quartiles were considered as high (H-NEFA) and low (L-NEFA) NEFA groups. Data were analyzed with correlation, linear regression, and proportional hazard regression models. Plasma NEFA concentration (H-NEFA mean ¼ 294 mM, SD ¼ 141.2; and L-NEFA mean ¼ 122 mM, SD ¼ 25.3) was correlated (P < 0.01) with plasma insulin (r2 = 0.374) and ghrelin (r2 = 0.346) concentrations but not with plasma GIP concentration (P = 0.64). The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 mU/mL of plasma insulin increase, there is a decrease of 1.223 +/- 0.62 mM of NEFA). Plasma ghrelin and GIP concentrations were not associated with plasma NEFA concentration. Finally, H-NEFA prepartum cows were less likely to resume ovulation than L-NEFA cows (hazard ratio [HR] = 0.563, 95% confidence interval [CI] = 0.314–1.011), whereas high ghrelin cows were more likely to resume ovulation than low ghrelin cows (HR = 1.873, 95% CI = 0.846–4.145). Conversely, resumption of ovulation was not associated with prepartum insulin and GIP concentrations. Prepartum NEFA and possibly ghrelin are associated with the return to postpartum cyclicity; however, insulin and GIP are not related to the resumption of ovulation in dairy cows. Facultad de Ciencias Veterinarias Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 62-67
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Prepartum NEFA
Prepartum ghrelin
Prepartum GIP
Resumption to ovarian activity
Dairy cow
spellingShingle Ciencias Veterinarias
Prepartum NEFA
Prepartum ghrelin
Prepartum GIP
Resumption to ovarian activity
Dairy cow
Miqueo, E.
Chiarle, Ayelén
Giuliodori, Mauricio Javier
Relling, Alejandro Enrique
Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
topic_facet Ciencias Veterinarias
Prepartum NEFA
Prepartum ghrelin
Prepartum GIP
Resumption to ovarian activity
Dairy cow
description Cows transitioning from late gestation to early lactation experience an increase in energy demands, which lead to a negative energy balance (NEB) because the greater energy requirement is not fully synchronized with the intake of dry matter. In this context, there is an increase in plasma NEFA and ghrelin concentrations and a decrease in plasma insulin and glucose-dependent insulinotropic polypeptide (GIP) concentrations. This situation could have a negative impact on the return to cyclicity because some of these variables have been associated with reduced GnRH and LH pulsatility (high NEFA and low insulin concentrations). However, there are no studies showing the relationship between ghrelin or GIP and reproductive performance. It is known that these hormones are related with lipolysis and NEB, with NEB being one of the main determinants of GnRH pulse generator activity. Thus, the objective of the present study was to evaluate the association between plasma NEFA concentration and metabolic hormones (insulin, ghrelin, and GIP) before parturition and their associations with the resumption of postpartum ovulations in dairy cows. A completely randomized block design was used in a commercial dairy herd with sampling day (visit to farm) as the blocking criteria. Holstein cows (n = 92) were screened for plasma NEFA concentration -5 d (+/-2 d) relative to the expected parturition day, and top and bottom quartiles were considered as high (H-NEFA) and low (L-NEFA) NEFA groups. Data were analyzed with correlation, linear regression, and proportional hazard regression models. Plasma NEFA concentration (H-NEFA mean ¼ 294 mM, SD ¼ 141.2; and L-NEFA mean ¼ 122 mM, SD ¼ 25.3) was correlated (P < 0.01) with plasma insulin (r2 = 0.374) and ghrelin (r2 = 0.346) concentrations but not with plasma GIP concentration (P = 0.64). The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 mU/mL of plasma insulin increase, there is a decrease of 1.223 +/- 0.62 mM of NEFA). Plasma ghrelin and GIP concentrations were not associated with plasma NEFA concentration. Finally, H-NEFA prepartum cows were less likely to resume ovulation than L-NEFA cows (hazard ratio [HR] = 0.563, 95% confidence interval [CI] = 0.314–1.011), whereas high ghrelin cows were more likely to resume ovulation than low ghrelin cows (HR = 1.873, 95% CI = 0.846–4.145). Conversely, resumption of ovulation was not associated with prepartum insulin and GIP concentrations. Prepartum NEFA and possibly ghrelin are associated with the return to postpartum cyclicity; however, insulin and GIP are not related to the resumption of ovulation in dairy cows.
format Articulo
Articulo
author Miqueo, E.
Chiarle, Ayelén
Giuliodori, Mauricio Javier
Relling, Alejandro Enrique
author_facet Miqueo, E.
Chiarle, Ayelén
Giuliodori, Mauricio Javier
Relling, Alejandro Enrique
author_sort Miqueo, E.
title Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
title_short Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
title_full Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
title_fullStr Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
title_full_unstemmed Association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
title_sort association between prepartum metabolic status and resumption of postpartum ovulation in dairy cows
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/159496
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AT chiarleayelen associationbetweenprepartummetabolicstatusandresumptionofpostpartumovulationindairycows
AT giuliodorimauriciojavier associationbetweenprepartummetabolicstatusandresumptionofpostpartumovulationindairycows
AT rellingalejandroenrique associationbetweenprepartummetabolicstatusandresumptionofpostpartumovulationindairycows
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