Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol

A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propanol) and timolol (S-[-]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and...

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Detalles Bibliográficos
Autores principales: Criado, Susana, Mártire, Daniel Osvaldo, Allegretti, Patricia Ercilia, Furlong, Jorge Javier Pedro, Bertolotti, Sonia, La Falce, E, García, Norman
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Química
photooxidation
pindolol
reaction mechanism
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/159211
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-159211
record_format dspace
spelling I19-R120-10915-1592112023-10-23T20:46:21Z http://sedici.unlp.edu.ar/handle/10915/159211 Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol Criado, Susana Mártire, Daniel Osvaldo Allegretti, Patricia Ercilia Furlong, Jorge Javier Pedro Bertolotti, Sonia La Falce, E García, Norman 2003 2023-10-23T14:07:29Z en Química photooxidation pindolol reaction mechanism A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propanol) and timolol (S-[-]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and the assumption that photooxidation mainly occurs through singlet molecular oxygen attack, a possible reaction mechanism is proposed. The mechanistic pathways involve singlet oxygen attack to the pindolol indole ring and oxidation of the pindolol isopropyl or timolol terbutyl methyl groups. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Laboratorio de Estudio de Compuestos Orgánicos Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 551-553
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
photooxidation
pindolol
reaction mechanism
spellingShingle Química
photooxidation
pindolol
reaction mechanism
Criado, Susana
Mártire, Daniel Osvaldo
Allegretti, Patricia Ercilia
Furlong, Jorge Javier Pedro
Bertolotti, Sonia
La Falce, E
García, Norman
Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
topic_facet Química
photooxidation
pindolol
reaction mechanism
description A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propanol) and timolol (S-[-]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and the assumption that photooxidation mainly occurs through singlet molecular oxygen attack, a possible reaction mechanism is proposed. The mechanistic pathways involve singlet oxygen attack to the pindolol indole ring and oxidation of the pindolol isopropyl or timolol terbutyl methyl groups.
format Articulo
Articulo
author Criado, Susana
Mártire, Daniel Osvaldo
Allegretti, Patricia Ercilia
Furlong, Jorge Javier Pedro
Bertolotti, Sonia
La Falce, E
García, Norman
author_facet Criado, Susana
Mártire, Daniel Osvaldo
Allegretti, Patricia Ercilia
Furlong, Jorge Javier Pedro
Bertolotti, Sonia
La Falce, E
García, Norman
author_sort Criado, Susana
title Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
title_short Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
title_full Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
title_fullStr Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
title_full_unstemmed Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
title_sort mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/159211
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