A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst
Substituted coumarins are synthesized from phenols and b-ketoesters by the Pechmann reaction, using a Wells–Dawson heteropolyacid (H6P2W18O62Æ24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130°C temperature and as little as 1mol% of Wells–Dawson acid, obtaining...
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2004
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/156371 |
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I19-R120-10915-156371 |
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I19-R120-10915-1563712023-08-16T04:06:12Z http://sedici.unlp.edu.ar/handle/10915/156371 A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst Romanelli, Gustavo Pablo Bennardi, Daniel Oscar Ruiz, Diego Manuel Baronetti, Graciela Teresita Thomas, Horacio Jorge Autino, Juan Carlos 2004 2023-08-15T18:08:03Z en Química Coumarin Heteropolyacid Wells–Dawson catalyst Pechmann reaction 4-Methylumbelliferone Substituted coumarins are synthesized from phenols and b-ketoesters by the Pechmann reaction, using a Wells–Dawson heteropolyacid (H6P2W18O62Æ24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130°C temperature and as little as 1mol% of Wells–Dawson acid, obtaining good to excellent yields of coumarins. The catalyst showed to be reusable with no differences in the yields. The results are compared with those of the reactions performed in toluene solution. The presented synthetic procedure is a convenient, clean and fast alternative for synthesizing 4-substituted coumarins (17 examples). Laboratorio de Estudio de Compuestos Orgánicos Centro de Investigación y Desarrollo en Ciencias Aplicadas Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y Técnicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 8935-8939 |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Química Coumarin Heteropolyacid Wells–Dawson catalyst Pechmann reaction 4-Methylumbelliferone |
| spellingShingle |
Química Coumarin Heteropolyacid Wells–Dawson catalyst Pechmann reaction 4-Methylumbelliferone Romanelli, Gustavo Pablo Bennardi, Daniel Oscar Ruiz, Diego Manuel Baronetti, Graciela Teresita Thomas, Horacio Jorge Autino, Juan Carlos A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| topic_facet |
Química Coumarin Heteropolyacid Wells–Dawson catalyst Pechmann reaction 4-Methylumbelliferone |
| description |
Substituted coumarins are synthesized from phenols and b-ketoesters by the Pechmann reaction, using a Wells–Dawson heteropolyacid (H6P2W18O62Æ24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130°C temperature and as little as 1mol% of Wells–Dawson acid, obtaining good to excellent yields of coumarins. The catalyst showed to be reusable with no differences in the yields. The results are compared with those of the reactions performed in toluene solution. The presented synthetic procedure is a convenient, clean and fast alternative for synthesizing 4-substituted coumarins (17 examples). |
| format |
Articulo Articulo |
| author |
Romanelli, Gustavo Pablo Bennardi, Daniel Oscar Ruiz, Diego Manuel Baronetti, Graciela Teresita Thomas, Horacio Jorge Autino, Juan Carlos |
| author_facet |
Romanelli, Gustavo Pablo Bennardi, Daniel Oscar Ruiz, Diego Manuel Baronetti, Graciela Teresita Thomas, Horacio Jorge Autino, Juan Carlos |
| author_sort |
Romanelli, Gustavo Pablo |
| title |
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| title_short |
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| title_full |
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| title_fullStr |
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| title_full_unstemmed |
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst |
| title_sort |
solvent-free synthesis of coumarins using a wells-dawson heteropolyacid as catalyst |
| publishDate |
2004 |
| url |
http://sedici.unlp.edu.ar/handle/10915/156371 |
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