Prodigiosin: a promising biomolecule with many potential biomedical applications

Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has mad...

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Detalles Bibliográficos
Autores principales: Islan, Germán Abel, Rodenak-Kladniew, Boris, Noacco, Nehuen, Duran, Nelson, Castro, Guillermo Raúl
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2022
Materias:
Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/154604
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-154604
record_format dspace
spelling I19-R120-10915-1546042023-06-23T20:07:08Z http://sedici.unlp.edu.ar/handle/10915/154604 issn:2165-5979 issn:2165-5987 Prodigiosin: a promising biomolecule with many potential biomedical applications Islan, Germán Abel Rodenak-Kladniew, Boris Noacco, Nehuen Duran, Nelson Castro, Guillermo Raúl 2022 2023-06-23T14:15:53Z en Bioquímica Ciencias Médicas Prodigiosin Serratia marcescens Prodigiosin production Prodigiosin biological activities Anticancer Antimicrobial Antifungal Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed. Centro de Investigación y Desarrollo en Fermentaciones Industriales Instituto de Investigaciones Bioquímicas de La Plata Articulo Revision http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 4227–14258
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
spellingShingle Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
Islan, Germán Abel
Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
Prodigiosin: a promising biomolecule with many potential biomedical applications
topic_facet Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
description Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.
format Articulo
Revision
author Islan, Germán Abel
Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
author_facet Islan, Germán Abel
Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
author_sort Islan, Germán Abel
title Prodigiosin: a promising biomolecule with many potential biomedical applications
title_short Prodigiosin: a promising biomolecule with many potential biomedical applications
title_full Prodigiosin: a promising biomolecule with many potential biomedical applications
title_fullStr Prodigiosin: a promising biomolecule with many potential biomedical applications
title_full_unstemmed Prodigiosin: a promising biomolecule with many potential biomedical applications
title_sort prodigiosin: a promising biomolecule with many potential biomedical applications
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/154604
work_keys_str_mv AT islangermanabel prodigiosinapromisingbiomoleculewithmanypotentialbiomedicalapplications
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AT durannelson prodigiosinapromisingbiomoleculewithmanypotentialbiomedicalapplications
AT castroguillermoraul prodigiosinapromisingbiomoleculewithmanypotentialbiomedicalapplications
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