Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment

A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix. ALG microspheres coated...

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Autores principales: Islan, Germán Abel, Bosio, Valeria Elizabeth, Castro, Guillermo Raúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Biología
alginate lyase
Biopolymers
Ciprofloxacin
Cystic fibrosis
Drug delivery
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/153221
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-153221
record_format dspace
spelling I19-R120-10915-1532212023-05-19T04:07:13Z http://sedici.unlp.edu.ar/handle/10915/153221 issn:1616-5195 Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment Islan, Germán Abel Bosio, Valeria Elizabeth Castro, Guillermo Raúl 2013 2023-05-18T17:06:21Z en Biología alginate lyase Biopolymers Ciprofloxacin Cystic fibrosis Drug delivery A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix. ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solvents mixtures, obtaining Cip encapsulations from 46.0 to 100.0%. ALG-HMP shows a Cip sustainable release profile and is able to encapsulate 90.0% of AL, showing 76.0% enzyme activity after release under simulated intestinal conditions. The developed system is a promising delivery carrier to treat chronic infection of Pseudomonas aeruginosa and to reduce the viscoelasticity of the mucus accumulated into intestine of CF patients. Centro de Investigación y Desarrollo en Fermentaciones Industriales Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
alginate lyase
Biopolymers
Ciprofloxacin
Cystic fibrosis
Drug delivery
spellingShingle Biología
alginate lyase
Biopolymers
Ciprofloxacin
Cystic fibrosis
Drug delivery
Islan, Germán Abel
Bosio, Valeria Elizabeth
Castro, Guillermo Raúl
Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
topic_facet Biología
alginate lyase
Biopolymers
Ciprofloxacin
Cystic fibrosis
Drug delivery
description A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix. ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solvents mixtures, obtaining Cip encapsulations from 46.0 to 100.0%. ALG-HMP shows a Cip sustainable release profile and is able to encapsulate 90.0% of AL, showing 76.0% enzyme activity after release under simulated intestinal conditions. The developed system is a promising delivery carrier to treat chronic infection of Pseudomonas aeruginosa and to reduce the viscoelasticity of the mucus accumulated into intestine of CF patients.
format Articulo
Articulo
author Islan, Germán Abel
Bosio, Valeria Elizabeth
Castro, Guillermo Raúl
author_facet Islan, Germán Abel
Bosio, Valeria Elizabeth
Castro, Guillermo Raúl
author_sort Islan, Germán Abel
title Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
title_short Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
title_full Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
title_fullStr Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
title_full_unstemmed Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
title_sort alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/153221
work_keys_str_mv AT islangermanabel alginatelyaseandciprofloxacincoimmobilizationonbiopolymericmicrospheresforcysticfibrosistreatment
AT bosiovaleriaelizabeth alginatelyaseandciprofloxacincoimmobilizationonbiopolymericmicrospheresforcysticfibrosistreatment
AT castroguillermoraul alginatelyaseandciprofloxacincoimmobilizationonbiopolymericmicrospheresforcysticfibrosistreatment
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