Controlled release biopolymers for enhancing the immune response

Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks re...

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Autores principales: Castro, Guillermo Raúl, Panilaitis, Bruce, Bora, Emilia, Kaplan, David L.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2007
Materias:
Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/152990
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-152990
record_format dspace
spelling I19-R120-10915-1529902023-05-16T04:06:47Z http://sedici.unlp.edu.ar/handle/10915/152990 issn:1543-8392 Controlled release biopolymers for enhancing the immune response Castro, Guillermo Raúl Panilaitis, Bruce Bora, Emilia Kaplan, David L. 2007 2023-05-15T14:59:54Z en Bioquímica Química Biología Emulsan β-glucan Controlled release Immunopotentiation Drug delivery Acinetobacter Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles. Centro de Investigación y Desarrollo en Fermentaciones Industriales Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
spellingShingle Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
Castro, Guillermo Raúl
Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
Controlled release biopolymers for enhancing the immune response
topic_facet Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
description Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles.
format Articulo
Articulo
author Castro, Guillermo Raúl
Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
author_facet Castro, Guillermo Raúl
Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
author_sort Castro, Guillermo Raúl
title Controlled release biopolymers for enhancing the immune response
title_short Controlled release biopolymers for enhancing the immune response
title_full Controlled release biopolymers for enhancing the immune response
title_fullStr Controlled release biopolymers for enhancing the immune response
title_full_unstemmed Controlled release biopolymers for enhancing the immune response
title_sort controlled release biopolymers for enhancing the immune response
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/152990
work_keys_str_mv AT castroguillermoraul controlledreleasebiopolymersforenhancingtheimmuneresponse
AT panilaitisbruce controlledreleasebiopolymersforenhancingtheimmuneresponse
AT boraemilia controlledreleasebiopolymersforenhancingtheimmuneresponse
AT kaplandavidl controlledreleasebiopolymersforenhancingtheimmuneresponse
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