Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells

The interaction of a poly-functional ligand derived of o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions, Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by...

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Detalles Bibliográficos
Autores principales: Rodríguez, María Rosa, Plá, Julián del, Balsa, Lucía Mariana, León, Ignacio Esteban, Piro, Oscar Enrique, Echeverría, Gustavo Alberto, García Tojal, Javier, Pis Diez, Reinaldo, Parajón Costa, Beatriz Susana, González Baró, Ana Cecilia
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2019
Materias:
Química
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/152756
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-152756
record_format dspace
spelling I19-R120-10915-1527562023-05-11T04:06:23Z http://sedici.unlp.edu.ar/handle/10915/152756 issn:1369-9261 Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells Rodríguez, María Rosa Plá, Julián del Balsa, Lucía Mariana León, Ignacio Esteban Piro, Oscar Enrique Echeverría, Gustavo Alberto García Tojal, Javier Pis Diez, Reinaldo Parajón Costa, Beatriz Susana González Baró, Ana Cecilia 2019 2023-05-10T18:51:21Z en Química The interaction of a poly-functional ligand derived of o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions, Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting as bidentate build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested. Centro de Química Inorgánica Instituto de Física La Plata Articulo Preprint http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
spellingShingle Química
Rodríguez, María Rosa
Plá, Julián del
Balsa, Lucía Mariana
León, Ignacio Esteban
Piro, Oscar Enrique
Echeverría, Gustavo Alberto
García Tojal, Javier
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
González Baró, Ana Cecilia
Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
topic_facet Química
description The interaction of a poly-functional ligand derived of o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions, Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting as bidentate build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested.
format Articulo
Preprint
author Rodríguez, María Rosa
Plá, Julián del
Balsa, Lucía Mariana
León, Ignacio Esteban
Piro, Oscar Enrique
Echeverría, Gustavo Alberto
García Tojal, Javier
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
González Baró, Ana Cecilia
author_facet Rodríguez, María Rosa
Plá, Julián del
Balsa, Lucía Mariana
León, Ignacio Esteban
Piro, Oscar Enrique
Echeverría, Gustavo Alberto
García Tojal, Javier
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
González Baró, Ana Cecilia
author_sort Rodríguez, María Rosa
title Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
title_short Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
title_full Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
title_fullStr Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
title_full_unstemmed Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene : Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
title_sort cu(ii) and zn(ii) complexes with a poly-functional ligand derived from o-vanillin and thiophene : crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/152756
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