Decidual cells and decidualization in the carnivoran endotheliochorial placenta

Decidualization is considered a distinctive feature of eutherian pregnancy, and has appeared during evolution along with the development of invasive forms of placentation, as the endotheliochorial placenta. Although decidualization is not massive in carnivores, as it is in most species developing he...

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Autores principales:	Diessler, Mónica Elizabeth, Hernández, Rocío, Gomez Castro, María Gimena, Barbeito, Claudio Gustavo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2023
Materias:	Ciencias Veterinarias Placenta Decidual Endotheliochorial Carnivore Feline Canine DSCs
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/152245
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-152245
record_format	dspace
spelling	I19-R120-10915-1522452024-10-03T14:45:13Z http://sedici.unlp.edu.ar/handle/10915/152245 Decidual cells and decidualization in the carnivoran endotheliochorial placenta Diessler, Mónica Elizabeth Hernández, Rocío Gomez Castro, María Gimena Barbeito, Claudio Gustavo 2023 2023-04-27T17:24:57Z en Ciencias Veterinarias Placenta Decidual Endotheliochorial Carnivore Feline Canine DSCs Decidualization is considered a distinctive feature of eutherian pregnancy, and has appeared during evolution along with the development of invasive forms of placentation, as the endotheliochorial placenta. Although decidualization is not massive in carnivores, as it is in most species developing hemochorial placentas, isolated or grouped cells regarded as decidual have been documented and characterized, mainly in bitches and queens. For the majority of the remaining species of the order, data in the bibliography are fragmentary. In this article, general morphological aspects of decidual stromal cells (DSCs), their time of appearance and lasting, data about the expression of cytoskeletal proteins and molecules considered as markers of decidualization were reviewed. From the data reviewed, it follows that carnivoran DSCs take part either in the secretion of progesterone, prostaglandins, relaxin, among other substances, or at least in the signaling pathways triggered by them. Beyond their physiological roles, some of those molecules are already being used, or are yet under study, for the noninvasive endocrine monitoring and reproductive control of domestic and wild carnivores. Only insulin-like growth factor binding protein 1, among the main decidual markers, has been undoubtedly demonstrated in both species. Laminin, on the contrary, was found only in feline DSCs, and prolactin was preliminary reported in dogs and cats. Prolactin receptor, on the other hand, was found in both species. While canine DSCs are the only placental cell type expressing the nuclear progesterone receptor (PGR), that receptor has not been demonstrated neither in feline DSCs, nor in any other cell in the queen placenta, although the use of PGR blockers leads to abortion. Against this background, and from the data gathered so far, it is unquestionable that DSCs in carnivorans do play a pivotal role in placental development and health. The knowledge about placental physiology is critical for medical care and breeding management, primarily in domestic carnivores; it is also absolutely crucial for a conservation approach in the management of endangered carnivore species. Facultad de Ciencias Veterinarias Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias Placenta Decidual Endotheliochorial Carnivore Feline Canine DSCs
spellingShingle	Ciencias Veterinarias Placenta Decidual Endotheliochorial Carnivore Feline Canine DSCs Diessler, Mónica Elizabeth Hernández, Rocío Gomez Castro, María Gimena Barbeito, Claudio Gustavo Decidual cells and decidualization in the carnivoran endotheliochorial placenta
topic_facet	Ciencias Veterinarias Placenta Decidual Endotheliochorial Carnivore Feline Canine DSCs
description	Decidualization is considered a distinctive feature of eutherian pregnancy, and has appeared during evolution along with the development of invasive forms of placentation, as the endotheliochorial placenta. Although decidualization is not massive in carnivores, as it is in most species developing hemochorial placentas, isolated or grouped cells regarded as decidual have been documented and characterized, mainly in bitches and queens. For the majority of the remaining species of the order, data in the bibliography are fragmentary. In this article, general morphological aspects of decidual stromal cells (DSCs), their time of appearance and lasting, data about the expression of cytoskeletal proteins and molecules considered as markers of decidualization were reviewed. From the data reviewed, it follows that carnivoran DSCs take part either in the secretion of progesterone, prostaglandins, relaxin, among other substances, or at least in the signaling pathways triggered by them. Beyond their physiological roles, some of those molecules are already being used, or are yet under study, for the noninvasive endocrine monitoring and reproductive control of domestic and wild carnivores. Only insulin-like growth factor binding protein 1, among the main decidual markers, has been undoubtedly demonstrated in both species. Laminin, on the contrary, was found only in feline DSCs, and prolactin was preliminary reported in dogs and cats. Prolactin receptor, on the other hand, was found in both species. While canine DSCs are the only placental cell type expressing the nuclear progesterone receptor (PGR), that receptor has not been demonstrated neither in feline DSCs, nor in any other cell in the queen placenta, although the use of PGR blockers leads to abortion. Against this background, and from the data gathered so far, it is unquestionable that DSCs in carnivorans do play a pivotal role in placental development and health. The knowledge about placental physiology is critical for medical care and breeding management, primarily in domestic carnivores; it is also absolutely crucial for a conservation approach in the management of endangered carnivore species.
format	Articulo Articulo
author	Diessler, Mónica Elizabeth Hernández, Rocío Gomez Castro, María Gimena Barbeito, Claudio Gustavo
author_facet	Diessler, Mónica Elizabeth Hernández, Rocío Gomez Castro, María Gimena Barbeito, Claudio Gustavo
author_sort	Diessler, Mónica Elizabeth
title	Decidual cells and decidualization in the carnivoran endotheliochorial placenta
title_short	Decidual cells and decidualization in the carnivoran endotheliochorial placenta
title_full	Decidual cells and decidualization in the carnivoran endotheliochorial placenta
title_fullStr	Decidual cells and decidualization in the carnivoran endotheliochorial placenta
title_full_unstemmed	Decidual cells and decidualization in the carnivoran endotheliochorial placenta
title_sort	decidual cells and decidualization in the carnivoran endotheliochorial placenta
publishDate	2023
url	http://sedici.unlp.edu.ar/handle/10915/152245
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Decidual cells and decidualization in the carnivoran endotheliochorial placenta

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