Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis

The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior)...

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Autores principales: Sánchez, A., Brun, L. R., Salerni, H., Costanzo, P. R., González, D., Bagur, A., Oliveri, B., Zanchetta, M. B., Farías, V., Maffei, L., Premrou, V., Mansur, José Luis, Larroudé, M. S., Sarli, M. A., Rey, P., Ulla, M. R., Pavlove, M. M., Karlsbrum, S., Brance, M. L.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Medicina
denosumab
bone mineral density
bone turnover markers
osteoporosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151985
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151985
record_format dspace
spelling I19-R120-10915-1519852023-04-21T20:38:47Z http://sedici.unlp.edu.ar/handle/10915/151985 issn:2090-8059 issn:2042-0064 Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis Sánchez, A. Brun, L. R. Salerni, H. Costanzo, P. R. González, D. Bagur, A. Oliveri, B. Zanchetta, M. B. Farías, V. Maffei, L. Premrou, V. Mansur, José Luis Larroudé, M. S. Sarli, M. A. Rey, P. Ulla, M. R. Pavlove, M. M. Karlsbrum, S. Brance, M. L. 2016 2023-04-21T17:59:58Z en Medicina denosumab bone mineral density bone turnover markers osteoporosis The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BPprior group compared with BP treated patients not switched to Dmab. Conclusion. Dmab treatment increased BMDand decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed. Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
denosumab
bone mineral density
bone turnover markers
osteoporosis
spellingShingle Medicina
denosumab
bone mineral density
bone turnover markers
osteoporosis
Sánchez, A.
Brun, L. R.
Salerni, H.
Costanzo, P. R.
González, D.
Bagur, A.
Oliveri, B.
Zanchetta, M. B.
Farías, V.
Maffei, L.
Premrou, V.
Mansur, José Luis
Larroudé, M. S.
Sarli, M. A.
Rey, P.
Ulla, M. R.
Pavlove, M. M.
Karlsbrum, S.
Brance, M. L.
Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
topic_facet Medicina
denosumab
bone mineral density
bone turnover markers
osteoporosis
description The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BPprior group compared with BP treated patients not switched to Dmab. Conclusion. Dmab treatment increased BMDand decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.
format Articulo
Articulo
author Sánchez, A.
Brun, L. R.
Salerni, H.
Costanzo, P. R.
González, D.
Bagur, A.
Oliveri, B.
Zanchetta, M. B.
Farías, V.
Maffei, L.
Premrou, V.
Mansur, José Luis
Larroudé, M. S.
Sarli, M. A.
Rey, P.
Ulla, M. R.
Pavlove, M. M.
Karlsbrum, S.
Brance, M. L.
author_facet Sánchez, A.
Brun, L. R.
Salerni, H.
Costanzo, P. R.
González, D.
Bagur, A.
Oliveri, B.
Zanchetta, M. B.
Farías, V.
Maffei, L.
Premrou, V.
Mansur, José Luis
Larroudé, M. S.
Sarli, M. A.
Rey, P.
Ulla, M. R.
Pavlove, M. M.
Karlsbrum, S.
Brance, M. L.
author_sort Sánchez, A.
title Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
title_short Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
title_full Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
title_fullStr Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
title_full_unstemmed Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
title_sort effect of denosumab on bone mineral density and markers of bone turnover among postmenopausal women with osteoporosis
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/151985
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