The depletion of doxycycline residues in poultry tissues

Doxycycline (DOX), tetracycline of second generation, is active against Gram+ and Gram- bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and c...

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Autores principales: Mestorino, Olga Nora, Daniele, Martín Rafael, Dadé, Martín Miguel, Buchamer, Andrea Verónica, Vedovato, Valeria Muriel, Marchetti, María Laura
Formato: Objeto de conferencia
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Veterinarias
Antibióticos
Residuos
Farmacocinética
Aves
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151876
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151876
record_format dspace
spelling I19-R120-10915-1518762023-04-21T04:08:28Z http://sedici.unlp.edu.ar/handle/10915/151876 The depletion of doxycycline residues in poultry tissues Mestorino, Olga Nora Daniele, Martín Rafael Dadé, Martín Miguel Buchamer, Andrea Verónica Vedovato, Valeria Muriel Marchetti, María Laura 2016 2016 2023-04-20T14:56:56Z en Ciencias Veterinarias Antibióticos Residuos Farmacocinética Aves Doxycycline (DOX), tetracycline of second generation, is active against Gram+ and Gram- bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. Our objective was to evaluate the withdrawal time (WT) of DOX formulation at 25% in edible tissues, after PO use in 40 healthy broilers (30-35 days of age). DOX was administered through medicated drinking water for 5 days at 10 mg kg-1 (N = 36). Four untreated animals were reserved as controls. Six animals per group were sacrificed by exsanguination, after 24 h until 9 d post treatment when control animals were sacrificed as well. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. The calculated WTs were 6.58, 8.18, 8.69 and 6.96 d for muscle, liver, kidney and skin/ fat, respectively. After DOX administration at a rate of 10 mg kg-1 for 5 days through the drinking water, the WT must be 9 d before treated chickens can be consumed. Facultad de Ciencias Veterinarias Objeto de conferencia Objeto de conferencia http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 592-596
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Antibióticos
Residuos
Farmacocinética
Aves
spellingShingle Ciencias Veterinarias
Antibióticos
Residuos
Farmacocinética
Aves
Mestorino, Olga Nora
Daniele, Martín Rafael
Dadé, Martín Miguel
Buchamer, Andrea Verónica
Vedovato, Valeria Muriel
Marchetti, María Laura
The depletion of doxycycline residues in poultry tissues
topic_facet Ciencias Veterinarias
Antibióticos
Residuos
Farmacocinética
Aves
description Doxycycline (DOX), tetracycline of second generation, is active against Gram+ and Gram- bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. Our objective was to evaluate the withdrawal time (WT) of DOX formulation at 25% in edible tissues, after PO use in 40 healthy broilers (30-35 days of age). DOX was administered through medicated drinking water for 5 days at 10 mg kg-1 (N = 36). Four untreated animals were reserved as controls. Six animals per group were sacrificed by exsanguination, after 24 h until 9 d post treatment when control animals were sacrificed as well. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. The calculated WTs were 6.58, 8.18, 8.69 and 6.96 d for muscle, liver, kidney and skin/ fat, respectively. After DOX administration at a rate of 10 mg kg-1 for 5 days through the drinking water, the WT must be 9 d before treated chickens can be consumed.
format Objeto de conferencia
Objeto de conferencia
author Mestorino, Olga Nora
Daniele, Martín Rafael
Dadé, Martín Miguel
Buchamer, Andrea Verónica
Vedovato, Valeria Muriel
Marchetti, María Laura
author_facet Mestorino, Olga Nora
Daniele, Martín Rafael
Dadé, Martín Miguel
Buchamer, Andrea Verónica
Vedovato, Valeria Muriel
Marchetti, María Laura
author_sort Mestorino, Olga Nora
title The depletion of doxycycline residues in poultry tissues
title_short The depletion of doxycycline residues in poultry tissues
title_full The depletion of doxycycline residues in poultry tissues
title_fullStr The depletion of doxycycline residues in poultry tissues
title_full_unstemmed The depletion of doxycycline residues in poultry tissues
title_sort depletion of doxycycline residues in poultry tissues
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/151876
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