Doxycycline residues in edible tissues of pigs

Doxycycline (DOX) is a variant of the tetracycline antimicrobial with similar properties, but with a longer action period. It is widely used in swine production. The presence of residues of antibiotics in food products of animal origin has a special toxicological interest due to their potential effe...

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Autores principales: Mestorino, Olga Nora, Daniele, Martín Rafael, Buchamer, Andrea Verónica, Chiarizia, Juan Cruz, Marchetti, María Laura
Formato: Objeto de conferencia
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Veterinarias
Antibióticos
Residuos
Porcinos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151873
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151873
record_format dspace
spelling I19-R120-10915-1518732023-04-21T04:08:30Z http://sedici.unlp.edu.ar/handle/10915/151873 Doxycycline residues in edible tissues of pigs Mestorino, Olga Nora Daniele, Martín Rafael Buchamer, Andrea Verónica Chiarizia, Juan Cruz Marchetti, María Laura 2016 2016 2023-04-20T14:52:02Z en Ciencias Veterinarias Antibióticos Residuos Porcinos Doxycycline (DOX) is a variant of the tetracycline antimicrobial with similar properties, but with a longer action period. It is widely used in swine production. The presence of residues of antibiotics in food products of animal origin has a special toxicological interest due to their potential effects on human health. Our aim was to evaluate the withdrawal time (WT) of DOX formulation (25%) in edible tissues of swine, after PO administration. Eighteen healthy young pigs (30-35 days old) were used. DOX was administered with drinking water during 5 days at 10 mg kg-1. Two animals, as the control group, were not treated. Four animals per group were sacrificed by exsanguination 24 hours until 11 days post-treatment. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. For muscle tissue, a WT of 4.3 days was determined. In other tissues, DOX concentrations were measured until 7-11 days post-administration. The WT was 7.2, 4.9 and 4.5 days for liver, kidney and skin/fat, respectively. After administration of DOX at 10 mg kg-1 for 5 days through medicated drinking water, a WT of 8 days must be set for safe consumption of medicated animals. Facultad de Ciencias Veterinarias Objeto de conferencia Objeto de conferencia http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 599-603
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Antibióticos
Residuos
Porcinos
spellingShingle Ciencias Veterinarias
Antibióticos
Residuos
Porcinos
Mestorino, Olga Nora
Daniele, Martín Rafael
Buchamer, Andrea Verónica
Chiarizia, Juan Cruz
Marchetti, María Laura
Doxycycline residues in edible tissues of pigs
topic_facet Ciencias Veterinarias
Antibióticos
Residuos
Porcinos
description Doxycycline (DOX) is a variant of the tetracycline antimicrobial with similar properties, but with a longer action period. It is widely used in swine production. The presence of residues of antibiotics in food products of animal origin has a special toxicological interest due to their potential effects on human health. Our aim was to evaluate the withdrawal time (WT) of DOX formulation (25%) in edible tissues of swine, after PO administration. Eighteen healthy young pigs (30-35 days old) were used. DOX was administered with drinking water during 5 days at 10 mg kg-1. Two animals, as the control group, were not treated. Four animals per group were sacrificed by exsanguination 24 hours until 11 days post-treatment. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. For muscle tissue, a WT of 4.3 days was determined. In other tissues, DOX concentrations were measured until 7-11 days post-administration. The WT was 7.2, 4.9 and 4.5 days for liver, kidney and skin/fat, respectively. After administration of DOX at 10 mg kg-1 for 5 days through medicated drinking water, a WT of 8 days must be set for safe consumption of medicated animals.
format Objeto de conferencia
Objeto de conferencia
author Mestorino, Olga Nora
Daniele, Martín Rafael
Buchamer, Andrea Verónica
Chiarizia, Juan Cruz
Marchetti, María Laura
author_facet Mestorino, Olga Nora
Daniele, Martín Rafael
Buchamer, Andrea Verónica
Chiarizia, Juan Cruz
Marchetti, María Laura
author_sort Mestorino, Olga Nora
title Doxycycline residues in edible tissues of pigs
title_short Doxycycline residues in edible tissues of pigs
title_full Doxycycline residues in edible tissues of pigs
title_fullStr Doxycycline residues in edible tissues of pigs
title_full_unstemmed Doxycycline residues in edible tissues of pigs
title_sort doxycycline residues in edible tissues of pigs
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/151873
work_keys_str_mv AT mestorinoolganora doxycyclineresiduesinedibletissuesofpigs
AT danielemartinrafael doxycyclineresiduesinedibletissuesofpigs
AT buchamerandreaveronica doxycyclineresiduesinedibletissuesofpigs
AT chiariziajuancruz doxycyclineresiduesinedibletissuesofpigs
AT marchettimarialaura doxycyclineresiduesinedibletissuesofpigs
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