Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders

Hippocampus serves as a pivotal role in cognitive and emotional processes, as well as in the regulation of the hypothalamus-pituitary axis. It is known to undergo mild neurodegenerative changes during normal aging and severe atrophy in Alzheimer’s disease. Furthermore, dysregulation in the hippocamp...

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Autores principales:	Chiavellini, Priscila, Canatelli Mallat, Martina, Lehmann, Marianne, Goya, Rodolfo Gustavo, Morel, Gustavo Ramón
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2021
Materias:	Ciencias Médicas aging Alzheimer’s disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/151826
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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spelling	I19-R120-10915-1518262023-04-20T04:08:31Z http://sedici.unlp.edu.ar/handle/10915/151826 issn:1876-7958 Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders Chiavellini, Priscila Canatelli Mallat, Martina Lehmann, Marianne Goya, Rodolfo Gustavo Morel, Gustavo Ramón 2021-08-04 2023-04-19T18:54:24Z en Ciencias Médicas aging Alzheimer’s disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression Hippocampus serves as a pivotal role in cognitive and emotional processes, as well as in the regulation of the hypothalamus-pituitary axis. It is known to undergo mild neurodegenerative changes during normal aging and severe atrophy in Alzheimer’s disease. Furthermore, dysregulation in the hippocampal function leads to epilepsy and mood disorders. In the first section, we summarized the most salient knowledge on the role of glial cell-line-derived neurotrophic factor and its receptors focused on aging, cognition and neurodegenerative and hippocampal-related neurological diseases mentioned above. In the second section, we reviewed the therapeutic approaches, particularly gene therapy, using glial cell-line-derived neurotrophic factor or its gene, as a key molecule in the development of neurological disorders. In the third section, we pointed at the potential of regenerative medicine, as an emerging and less explored strategy for the treatment of hippocampal disorders. We briefly reviewed the use of partial reprogramming to restore brain functions, non-neuronal cell reprogramming to generate neural stem cells, and neural progenitor cells as source-specific neuronal types to be implanted in animal models of specific neurodegenerative disorders. Instituto de Investigaciones Bioquímicas de La Plata Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 469-476
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas aging Alzheimer’s disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression
spellingShingle	Ciencias Médicas aging Alzheimer’s disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression Chiavellini, Priscila Canatelli Mallat, Martina Lehmann, Marianne Goya, Rodolfo Gustavo Morel, Gustavo Ramón Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
topic_facet	Ciencias Médicas aging Alzheimer’s disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression
description	Hippocampus serves as a pivotal role in cognitive and emotional processes, as well as in the regulation of the hypothalamus-pituitary axis. It is known to undergo mild neurodegenerative changes during normal aging and severe atrophy in Alzheimer’s disease. Furthermore, dysregulation in the hippocampal function leads to epilepsy and mood disorders. In the first section, we summarized the most salient knowledge on the role of glial cell-line-derived neurotrophic factor and its receptors focused on aging, cognition and neurodegenerative and hippocampal-related neurological diseases mentioned above. In the second section, we reviewed the therapeutic approaches, particularly gene therapy, using glial cell-line-derived neurotrophic factor or its gene, as a key molecule in the development of neurological disorders. In the third section, we pointed at the potential of regenerative medicine, as an emerging and less explored strategy for the treatment of hippocampal disorders. We briefly reviewed the use of partial reprogramming to restore brain functions, non-neuronal cell reprogramming to generate neural stem cells, and neural progenitor cells as source-specific neuronal types to be implanted in animal models of specific neurodegenerative disorders.
format	Articulo Articulo
author	Chiavellini, Priscila Canatelli Mallat, Martina Lehmann, Marianne Goya, Rodolfo Gustavo Morel, Gustavo Ramón
author_facet	Chiavellini, Priscila Canatelli Mallat, Martina Lehmann, Marianne Goya, Rodolfo Gustavo Morel, Gustavo Ramón
author_sort	Chiavellini, Priscila
title	Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
title_short	Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
title_full	Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
title_fullStr	Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
title_full_unstemmed	Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
title_sort	therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders
publishDate	2021
url	http://sedici.unlp.edu.ar/handle/10915/151826
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Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders

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