Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states

Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectr...

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Autores principales: Gonzalez, M. Micaela, Denofrio, María Paula, García Einschlag, Fernando Sebastián, Franca, Carlos Alberto, Pis Diez, Reinaldo, Erra-Balsells, Rosa, Cabrerizo, Franco Martín
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151512
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151512
record_format dspace
spelling I19-R120-10915-1515122023-04-15T04:06:27Z http://sedici.unlp.edu.ar/handle/10915/151512 issn:1463-9076 issn:1463-9084 Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states Gonzalez, M. Micaela Denofrio, María Paula García Einschlag, Fernando Sebastián Franca, Carlos Alberto Pis Diez, Reinaldo Erra-Balsells, Rosa Cabrerizo, Franco Martín 2014-08 2023-04-14T18:11:01Z en Química Física Beta-Carbolines Alkaloids Nitrogen Heterocycles Nucleotides Self Assemby Heteroassociaton Chemometrics Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane. Centro de Química Inorgánica Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Articulo Articulo http://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution 3.0 Unported (CC BY 3.0) application/pdf 16547-16562
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
spellingShingle Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
Gonzalez, M. Micaela
Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
topic_facet Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
description Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.
format Articulo
Articulo
author Gonzalez, M. Micaela
Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
author_facet Gonzalez, M. Micaela
Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
author_sort Gonzalez, M. Micaela
title Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_short Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_fullStr Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full_unstemmed Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_sort determining the molecular basis for the ph-dependent interaction between 2′-deoxynucleotides and 9h-pyrido[3,4-b]indole in its ground and electronic excited states
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/151512
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