Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria

Cellular metabolic changes during kidney disease may induce higher production of oxygen radicals that play a significant role in the progression of renal damage and in the onset of important comorbidities. In the study reported here the effect of Calendula Officinalis L. extract (CO) on chemilumines...

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Autores principales:	Gavazza, Mariana Beatriz, Marmunti, Monica Edith, Zeinsteger, Pedro Adolfo, Barberón, Javier Leandro, Palacios, Alejandro
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2017
Materias:	Ciencias Veterinarias Calendula officinalis L. (Asteraceae) peroxidation chemiluminescence mitochondria microsomes
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/150738 https://www.appliedcellbiology.com/abs-protective-effect-of-calendula-officinalis-l-extract-against-non-enzymatic-peroxidation-124.php
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias Calendula officinalis L. (Asteraceae) peroxidation chemiluminescence mitochondria microsomes
spellingShingle	Ciencias Veterinarias Calendula officinalis L. (Asteraceae) peroxidation chemiluminescence mitochondria microsomes Gavazza, Mariana Beatriz Marmunti, Monica Edith Zeinsteger, Pedro Adolfo Barberón, Javier Leandro Palacios, Alejandro Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
topic_facet	Ciencias Veterinarias Calendula officinalis L. (Asteraceae) peroxidation chemiluminescence mitochondria microsomes
description	Cellular metabolic changes during kidney disease may induce higher production of oxygen radicals that play a significant role in the progression of renal damage and in the onset of important comorbidities. In the study reported here the effect of Calendula Officinalis L. extract (CO) on chemiluminescence of mitochondria and microsomes isolated from kidney rat was analysed. After incubation of mitochondria and microsomes in an ascorbate (0.4 mM)-Fe++ (2.15 μM) system (180 min at 37°C), non-enzymatic peroxidation, it was observed that the total cpm/mg protein originated from light emission: chemiluminescence was lower in kidney mitochondria and microsomes obtained from CO group than in the control group (without CO). Moreover, it was observed that the CO was reduced, concentration dependent (0.05, 0.25, 0.35 and 0.45 mg of extract), of chemiluminescence, measured as total cpm. The analyses of chemiluminescence indicate that CO may act as antioxidant protecting rat kidney mitochondria and microsomes from peroxidative damage.
format	Articulo Articulo
author	Gavazza, Mariana Beatriz Marmunti, Monica Edith Zeinsteger, Pedro Adolfo Barberón, Javier Leandro Palacios, Alejandro
author_facet	Gavazza, Mariana Beatriz Marmunti, Monica Edith Zeinsteger, Pedro Adolfo Barberón, Javier Leandro Palacios, Alejandro
author_sort	Gavazza, Mariana Beatriz
title	Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
title_short	Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
title_full	Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
title_fullStr	Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
title_full_unstemmed	Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
title_sort	protective effect of <i>calendula officinalis</i> l. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/150738 https://www.appliedcellbiology.com/abs-protective-effect-of-calendula-officinalis-l-extract-against-non-enzymatic-peroxidation-124.php
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bdutipo_str	Repositorios
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Protective effect of <i>Calendula Officinalis</i> L. extract against non-enzymatic peroxidation of rat kidney microsomes and mitochondria

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