Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas

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In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intra-patient variations related to daily insulin sensitivity (S...

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Autores principales: Moscoso Vásquez, Marcela, Colmegna, Patricio Hernán, Rosales, Nicolás, Garelli, Fabricio, Sánchez Peña, Ricardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ingeniería Electrónica
Intra-patient variations
LPV model
type 1 diabetes
control-oriented model
artificial pancreas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/149291
https://ieeexplore.ieee.org/document/8970365
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-149291
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería Electrónica
Intra-patient variations
LPV model
type 1 diabetes
control-oriented model
artificial pancreas
spellingShingle Ingeniería Electrónica
Intra-patient variations
LPV model
type 1 diabetes
control-oriented model
artificial pancreas
Moscoso Vásquez, Marcela
Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sánchez Peña, Ricardo
Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
topic_facet Ingeniería Electrónica
Intra-patient variations
LPV model
type 1 diabetes
control-oriented model
artificial pancreas
description In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intra-patient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-orientedmodel which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM control-oriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation.
format Articulo
Articulo
author Moscoso Vásquez, Marcela
Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sánchez Peña, Ricardo
author_facet Moscoso Vásquez, Marcela
Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sánchez Peña, Ricardo
author_sort Moscoso Vásquez, Marcela
title Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
title_short Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
title_full Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
title_fullStr Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
title_full_unstemmed Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
title_sort control-oriented model with intra-patient variations for an artificial pancreas
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/149291
https://ieeexplore.ieee.org/document/8970365
work_keys_str_mv AT moscosovasquezmarcela controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT colmegnapatriciohernan controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT rosalesnicolas controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT garellifabricio controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT sanchezpenaricardo controlorientedmodelwithintrapatientvariationsforanartificialpancreas
bdutipo_str Repositorios
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