A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves

Background: Dihydrofurocoumarins are a large family of compounds, among them, dihydroangelicins and dihydropsoralens, are present in various plant species with varied biological activity. Several strategies have been developed for synthesizing these compounds and various catalysts have been used for...

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Autores principales: Ruiz, Diego Manuel, Autino, Juan Carlos, Romanelli, Gustavo Pablo
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2016
Materias:
Química
Dihydroangelicins
Dihydrofuocoumarins
Microwave radiation
Green chemistry
Heteopolyacid
Preyysler structure
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/148964
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-148964
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Dihydroangelicins
Dihydrofuocoumarins
Microwave radiation
Green chemistry
Heteopolyacid
Preyysler structure
spellingShingle Química
Dihydroangelicins
Dihydrofuocoumarins
Microwave radiation
Green chemistry
Heteopolyacid
Preyysler structure
Ruiz, Diego Manuel
Autino, Juan Carlos
Romanelli, Gustavo Pablo
A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
topic_facet Química
Dihydroangelicins
Dihydrofuocoumarins
Microwave radiation
Green chemistry
Heteopolyacid
Preyysler structure
description Background: Dihydrofurocoumarins are a large family of compounds, among them, dihydroangelicins and dihydropsoralens, are present in various plant species with varied biological activity. Several strategies have been developed for synthesizing these compounds and various catalysts have been used for this purpose. Methods: In this work, we report the synthesis of 8,9-dihydrofuran [2, 3-h] coumarins using allyloxycoumarin cycloaddition in sustainable conditions: absence of solvents, application of microwave radiation, and insoluble acid catalysis by means of heteropolyacids with Preyssler structure, [H14(NaP5MoW29O110)]. Conclusion: With these conditions, and testing sustainability by means of Eco-Scale and E-factor, we replace the use of solvents and mineral acids having a great impact on the environment with a solid, easily recoverable heteropolyacid.
format Articulo
Preprint
author Ruiz, Diego Manuel
Autino, Juan Carlos
Romanelli, Gustavo Pablo
author_facet Ruiz, Diego Manuel
Autino, Juan Carlos
Romanelli, Gustavo Pablo
author_sort Ruiz, Diego Manuel
title A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
title_short A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
title_full A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
title_fullStr A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
title_full_unstemmed A Solvent-free Method for Synthesis of Dihydroangelicins using Microwaves
title_sort solvent-free method for synthesis of dihydroangelicins using microwaves
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/148964
work_keys_str_mv AT ruizdiegomanuel asolventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
AT autinojuancarlos asolventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
AT romanelligustavopablo asolventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
AT ruizdiegomanuel solventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
AT autinojuancarlos solventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
AT romanelligustavopablo solventfreemethodforsynthesisofdihydroangelicinsusingmicrowaves
bdutipo_str Repositorios
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