ACE2 a double-edged sword?

Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins -...

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Autores principales: Campagnole Santos, Maria Jose, Santos, Robson A. S., Magalhaes, Gisele S., Motta Santos, Daisy, Rodrigues Machado, Maria da Glória
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Médicas
Coronavirus
ACE2
Proteínas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/148827
https://pmr.safisiol.org.ar/wp-content/uploads/2022/12/special_issue_coronavirus_2020.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-148827
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Coronavirus
ACE2
Proteínas
spellingShingle Ciencias Médicas
Coronavirus
ACE2
Proteínas
Campagnole Santos, Maria Jose
Santos, Robson A. S.
Magalhaes, Gisele S.
Motta Santos, Daisy
Rodrigues Machado, Maria da Glória
ACE2 a double-edged sword?
topic_facet Ciencias Médicas
Coronavirus
ACE2
Proteínas
description Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%).
format Articulo
Articulo
author Campagnole Santos, Maria Jose
Santos, Robson A. S.
Magalhaes, Gisele S.
Motta Santos, Daisy
Rodrigues Machado, Maria da Glória
author_facet Campagnole Santos, Maria Jose
Santos, Robson A. S.
Magalhaes, Gisele S.
Motta Santos, Daisy
Rodrigues Machado, Maria da Glória
author_sort Campagnole Santos, Maria Jose
title ACE2 a double-edged sword?
title_short ACE2 a double-edged sword?
title_full ACE2 a double-edged sword?
title_fullStr ACE2 a double-edged sword?
title_full_unstemmed ACE2 a double-edged sword?
title_sort ace2 a double-edged sword?
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/148827
https://pmr.safisiol.org.ar/wp-content/uploads/2022/12/special_issue_coronavirus_2020.pdf
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AT santosrobsonas ace2adoubleedgedsword
AT magalhaesgiseles ace2adoubleedgedsword
AT mottasantosdaisy ace2adoubleedgedsword
AT rodriguesmachadomariadagloria ace2adoubleedgedsword
bdutipo_str Repositorios
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