TRP channels as biological sensors

TRP is the most recently discovered family of ion channels and display the largest structure and function diversity among ion channels. Most TRP channels are key elements in sensory cells, where they are involved in the response to a broad range of external stimuli such as light, sound, chemicals, t...

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Detalles Bibliográficos
Autores principales: Astorga, Guadalupe, Bacigalupo, Juan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Ciencias Médicas
TRP
Drosophila
Genética
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/148575
https://pmr.safisiol.org.ar/issue/trp-channels-as-biological-sensors/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-148575
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
TRP
Drosophila
Genética
spellingShingle Ciencias Médicas
TRP
Drosophila
Genética
Astorga, Guadalupe
Bacigalupo, Juan
TRP channels as biological sensors
topic_facet Ciencias Médicas
TRP
Drosophila
Genética
description TRP is the most recently discovered family of ion channels and display the largest structure and function diversity among ion channels. Most TRP channels are key elements in sensory cells, where they are involved in the response to a broad range of external stimuli such as light, sound, chemicals, temperature and touch. In addition, cells detect changes in their local environment, like osmolarity and oxidative stress, by means of TRP channels. They have been found in eukaryotes like yeasts, worms, insects, fishes, birds, and mammals. In mammals, they are present in a wide range of organs and cells including central and peripheral nervous system. TRP channels were discovered in Drosophila photoreceptors, in a mutant that elicits a transient rather than maintained receptor potential in response to a sustained light stimulus. For this reason, this gene was termed transient receptor potential or trp. This mutation causes a ~10-fold reduction in the light induced Ca2+ influx to the photoreceptor (3, 6).
format Articulo
Articulo
author Astorga, Guadalupe
Bacigalupo, Juan
author_facet Astorga, Guadalupe
Bacigalupo, Juan
author_sort Astorga, Guadalupe
title TRP channels as biological sensors
title_short TRP channels as biological sensors
title_full TRP channels as biological sensors
title_fullStr TRP channels as biological sensors
title_full_unstemmed TRP channels as biological sensors
title_sort trp channels as biological sensors
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/148575
https://pmr.safisiol.org.ar/issue/trp-channels-as-biological-sensors/
work_keys_str_mv AT astorgaguadalupe trpchannelsasbiologicalsensors
AT bacigalupojuan trpchannelsasbiologicalsensors
bdutipo_str Repositorios
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