Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
A significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, r...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/147284 |
| Aporte de: |
| Sumario: | A significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, rendering them ineffective, and whether its action can be reversed by its natural inhibitor, Elafin. |
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