Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD

A significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, r...

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Detalles Bibliográficos
Autores principales: Kok, Klaartje, Curciarello, Renata, Sobande, T., Jones, S., Docena, Guillermo Horacio, MacDonald, Thomas T.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/147284
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-147284
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
spellingShingle Ciencias Médicas
Kok, Klaartje
Curciarello, Renata
Sobande, T.
Jones, S.
Docena, Guillermo Horacio
MacDonald, Thomas T.
Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
topic_facet Ciencias Médicas
description A significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, rendering them ineffective, and whether its action can be reversed by its natural inhibitor, Elafin.
format Articulo
Comunicacion
author Kok, Klaartje
Curciarello, Renata
Sobande, T.
Jones, S.
Docena, Guillermo Horacio
MacDonald, Thomas T.
author_facet Kok, Klaartje
Curciarello, Renata
Sobande, T.
Jones, S.
Docena, Guillermo Horacio
MacDonald, Thomas T.
author_sort Kok, Klaartje
title Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
title_short Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
title_full Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
title_fullStr Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
title_full_unstemmed Human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in IBD
title_sort human neutrophil elastase degrades the therapeutic monoclonal antibodies effective in ibd
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/147284
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