Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy

Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defi...

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Detalles Bibliográficos
Autores principales: Lazarowski, Alberto, Czornyj, Liliana, Girardi, Elena
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2006
Materias:
Ciencias Médicas
Epilepsy
P-glycoprotein
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/147248
https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol2_n3_october.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-147248
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Epilepsy
P-glycoprotein
spellingShingle Ciencias Médicas
Epilepsy
P-glycoprotein
Lazarowski, Alberto
Czornyj, Liliana
Girardi, Elena
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
topic_facet Ciencias Médicas
Epilepsy
P-glycoprotein
description Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.
format Articulo
Revision
author Lazarowski, Alberto
Czornyj, Liliana
Girardi, Elena
author_facet Lazarowski, Alberto
Czornyj, Liliana
Girardi, Elena
author_sort Lazarowski, Alberto
title Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_short Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_full Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_fullStr Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_full_unstemmed Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_sort clinical and experimental evidences for a role of abc transporters in the mechanisms underlying multidrug resistance in epilepsy
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/147248
https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol2_n3_october.pdf
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