Role of transforming growth factor β1 as modulator of endothelial L-Arginine/ nitric oxide signalling pathway
TGF-β is one of the members of the TGF-β superfamily of growth factors, including activins/inhibins and bone morphogenic proteins (BMP). At least three TGF-β isoforms have been reported in mammals: TGF-β1, TGF-β2 and TGF-β3. Virtually all human cells produce TGF-β and express its plasma membrane rec...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo Revision |
| Lenguaje: | Inglés |
| Publicado: |
2006
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/146981 https://pmr.safisiol.org.ar/wp-content/uploads/2022/09/vol1_n11_june.pdf |
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I19-R120-10915-146981 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Fisiología TGF-β Growth factors |
| spellingShingle |
Ciencias Médicas Fisiología TGF-β Growth factors Vásquez, Rodrigo Sobrevia, Luis Role of transforming growth factor β1 as modulator of endothelial L-Arginine/ nitric oxide signalling pathway |
| topic_facet |
Ciencias Médicas Fisiología TGF-β Growth factors |
| description |
TGF-β is one of the members of the TGF-β superfamily of growth factors, including activins/inhibins and bone morphogenic proteins (BMP). At least three TGF-β isoforms have been reported in mammals: TGF-β1, TGF-β2 and TGF-β3. Virtually all human cells produce TGF-β and express its plasma membrane receptors. Each isoform is coded by a different gene, in a tissue-specific and developmental-regulated manner. TGF-β1 mRNA is expressed in endothelial, haematopoietic and connective-tissue cells, TGF-β2 mRNA is expressed in epithelial and neuronal cells, and TGF-β3 mRNA in mesenchymal cells (1,3,25). The sequence homology is 70-80% between TGF-β isoforms and 30-40% with activins/inhibins and BMP. TGF-β1, 2 and 3 are highly conserved in mammals suggesting a critical biological function for each of these isoforms, acting as strong mediators of tissue repair through chemotaxis and angiogenesis stimulation and extracellular matrix generation (1,3,25).
TGF-β1 is a 112 amino acid polypeptide which forms a homodimer with both subunits linked with a disulfide bond. TGF-β1 is synthesized as a precursor of 391 amino acids whose amino acid sequence includes TGF-β1 and the propeptide latencyassociated peptide (LAP) in the amino terminal. TGF-β1 is cleaved from LAP before the precursor is secreted from the cells, but it continues non-covalently bond to this propeptide. After being secreted, TGF-β1 is stored at the extracellular matrix as a complex formed between TGF-β1, LAP and the latent TGF-b binding protein (LTBP). The relation between TGF-β1 and LTBP through disulfide bond prevents the binding of TGF-β1 to its receptors. In vivo, TGF-β1 is released from the complex by the matrix glycoprotein thrombospondin 1 (TSP-1), which changes the conformation of LTBP (1,25). |
| format |
Articulo Revision |
| author |
Vásquez, Rodrigo Sobrevia, Luis |
| author_facet |
Vásquez, Rodrigo Sobrevia, Luis |
| author_sort |
Vásquez, Rodrigo |
| title |
Role of transforming growth factor β1 as modulator of endothelial L-Arginine/
nitric oxide signalling pathway |
| title_short |
Role of transforming growth factor β1 as modulator of endothelial L-Arginine/
nitric oxide signalling pathway |
| title_full |
Role of transforming growth factor β1 as modulator of endothelial L-Arginine/
nitric oxide signalling pathway |
| title_fullStr |
Role of transforming growth factor β1 as modulator of endothelial L-Arginine/
nitric oxide signalling pathway |
| title_full_unstemmed |
Role of transforming growth factor β1 as modulator of endothelial L-Arginine/
nitric oxide signalling pathway |
| title_sort |
role of transforming growth factor β1 as modulator of endothelial l-arginine/
nitric oxide signalling pathway |
| publishDate |
2006 |
| url |
http://sedici.unlp.edu.ar/handle/10915/146981 https://pmr.safisiol.org.ar/wp-content/uploads/2022/09/vol1_n11_june.pdf |
| work_keys_str_mv |
AT vasquezrodrigo roleoftransforminggrowthfactorb1asmodulatorofendotheliallargininenitricoxidesignallingpathway AT sobrevialuis roleoftransforminggrowthfactorb1asmodulatorofendotheliallargininenitricoxidesignallingpathway |
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Repositorios |
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1764820460729532417 |