Na⁺/H⁺ exchanger and myocardial growth
The stretching of a papillary muscle induces a sudden and immediate rise in force, due to an augmentation in myofilament Ca²⁺ responsiveness. During the next 10 to 15 minutes a progressive increase in force develops known as the “slow force response” (SFR), that is due to a progressive increase in C...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo Revision |
| Lenguaje: | Inglés |
| Publicado: |
2005
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/146969 https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n3_october.pdf |
| Aporte de: |
| id |
I19-R120-10915-146969 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Fisiología Myocardial stretch |
| spellingShingle |
Ciencias Médicas Fisiología Myocardial stretch Cingolani, Horacio Eugenio Ennis, Irene Lucía Na⁺/H⁺ exchanger and myocardial growth |
| topic_facet |
Ciencias Médicas Fisiología Myocardial stretch |
| description |
The stretching of a papillary muscle induces a sudden and immediate rise in force, due to an augmentation in myofilament Ca²⁺ responsiveness. During the next 10 to 15 minutes a progressive increase in force develops known as the “slow force response” (SFR), that is due to a progressive increase in Ca²⁺ transient amplitude. The source for this increase in Ca²⁺ transient remained obscure until we proposed a link between Ca²⁺ influx mediated by Na⁺/ Ca²⁺ (NCX) exchange in reverse mode and the activation of the Na⁺/H⁺ exchanger (NHE-1) caused by stretch;1-4 being the increase in the Ca²⁺ transient secondary to the increase in intracellular Na⁺ concentration ([Na+]i). It is known that the increase in [Na⁺]i can induce an increase in intracellular Ca²⁺ levels ([Ca²⁺ ]i) through the NCX either as a result of a decrease in Ca²⁺ efflux (decreased forward mode) or an increase in Ca²⁺ entry (increased reverse mode). The fact that after myocardial stretch there is no increase in diastolic [Ca²⁺ ]i 1,5 as would be expected for a decrease in Ca²⁺ efflux, suggests that the reverse mode of NCX is the mechanism involved in the increase in Ca²⁺ transient.1The SFR, the increase in [Na⁺]i and the increase in Ca²⁺ transient can be abolished by blocking the Angiotensin II (Ang II) AT1 receptors with losartan; the endothelin (ET) ETA receptors by BQ123 and by inhibition of the NHE-1.6 |
| format |
Articulo Revision |
| author |
Cingolani, Horacio Eugenio Ennis, Irene Lucía |
| author_facet |
Cingolani, Horacio Eugenio Ennis, Irene Lucía |
| author_sort |
Cingolani, Horacio Eugenio |
| title |
Na⁺/H⁺ exchanger and myocardial growth |
| title_short |
Na⁺/H⁺ exchanger and myocardial growth |
| title_full |
Na⁺/H⁺ exchanger and myocardial growth |
| title_fullStr |
Na⁺/H⁺ exchanger and myocardial growth |
| title_full_unstemmed |
Na⁺/H⁺ exchanger and myocardial growth |
| title_sort |
na⁺/h⁺ exchanger and myocardial growth |
| publishDate |
2005 |
| url |
http://sedici.unlp.edu.ar/handle/10915/146969 https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n3_october.pdf |
| work_keys_str_mv |
AT cingolanihoracioeugenio nahexchangerandmyocardialgrowth AT ennisirenelucia nahexchangerandmyocardialgrowth |
| bdutipo_str |
Repositorios |
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1764820460687589378 |